Title:The Prognostic Value and Clinical Significance of lncRNA SNHG5 Expression in Patients with Multiple Malignancies: A Bioinformatic and Meta-analysis
Volume: 24
Issue: 12
Author(s): Mehran Pashirzad and Amirhossein Sahebkar*
Affiliation:
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences,
Mashhad, Iran
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
lncRNA SNHG5, gene, overall survival, human cancer, GenomicScape, prognostic biomarker.
Abstract:
Background: Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA SNHG5)
has been identified as both a promising target for treatment and a predictor of prognosis in
diverse types of cancer. The objective of this study was to assess whether lncRNA SNHG5 expression
can be utilized as a prognostic biomarker for human cancer.
Methods: To ensure a thorough search of the literature for relevant English studies published before
July 2023, several databases were searched, including PubMed, Web of Science, ProQuest,
Cochrane Library, and Google Scholar. The study evaluated the impact of lncRNA SNHG5 on the
overall survival (OS) of cancer by calculating the pooled hazard ratio (HR) and odds ratio (OR)
with 95% confidence intervals (CIs). To further confirm the accuracy of the findings, the study investigated
the expression profile and prognostic significance of lncRNA SNHG5 through the use
of GenomicScape, OncoLnc, Kaplan-Meier plotter, and GEPIA databases.
Results: In this study, 995 patients were examined across a total of fourteen original studies. The
findings indicated that there was a significant relationship between heightened lncRNA SNHG5
expression and reduced OS, as evidenced by both univariate and multivariate analyses (HR =
1.89; 95% CI, 1.44-2.49; p < 0.001; HR = 3.97; 95% CI, 1.80-8.73; p < 0.001, respectively).
Pooled OR analysis showed a significant association between over-expression of lncRNA SNHG5
with advanced histological grade (OR = 0.28; 95% CI, 0.11-0.71; p = 0.007), present lymph node
metastasis (LNM; OR = 4.28; 95% CI, 2.47-7.43; p < 0.001), and smoking history (OR = 0.27;
95% CI, 0.15-0.49; p < 0.001). Bioinformatic databases confirmed that elevated SNHG5 expression
was significantly linked to poor prognosis in cancer patients, including colorectal cancer (CRC),
acute myeloid leukemia (AML), and esophageal adenocarcinoma (ESAD), and a longer OS in
patients with uterine corpus endometrial carcinoma (UCEC).
Conclusion: These results suggest that lncRNA SNHG5 may serve as an adverse prognostic biomarker
in several human cancers. Further investigations are needed to better understand the underlying
mechanisms that link lncRNA SNHG5 to multiple malignancies.
