Title:Cyclodepsipeptides: Isolation, Bioactivities, Biosynthesis and Total Synthesis
Volume: 22
Issue: 1
Author(s): Ning Chen, Xue Tian, Bing Liu*, Ting Zhu, Jintong Zhao and Ting Li
Affiliation:
- Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, China
- National
Anti Tumor Natural Drug Engineering Research Center of Ministry of Education of Harbin University of Commerce,
Harbin, China
Keywords:
Cyclodepsipeptides, antibacterial, isolation, bioactivities, biosynthesis, total synthesis.
Abstract: Cyclodepsipeptides, mainly derived from marine organisms and soil microorganisms, are
amphiphilic molecules consisting of short oligopeptides with fatty acid tails attached to form a macrocyclic
structure. Studies on the activity of cyclodepsipeptides have shown that they have cytotoxicity,
antibacterial and anthelmintic effects, and are widely used in biological control, drug development,
environmental remediation and disease treatment. Cyclodepsipeptides play a prominent role
in the development of new drugs and drug lead compounds, especially as antibiotics with great medicinal
potentiall, and are slowly seeping into the public consciousness. The biosynthesis of cyclodepsipeptides
is mainly based on the synthesis of non-ribosomal peptide synthases, and selection
of key regulatory enzymes for homologue regulation and biosynthetic strategies using genetic engineering
and metabolic engineering approaches. The biosynthesis method is miniaturised, recyclable,
and safer. The total synthesis methods of cyclodepsipeptides are mainly combined solid-liquid
phase methods, which synthesise cyclodepsipeptides faster and are easy to purify. This paper reviews
the biological activities of cyclodepsipeptides, their biosynthesis, and total synthesis.
