Title:Transfersomes: Recent Advances, Mechanisms, Exhaustive Applications, Clinical Trials, and Patents
Volume: 22
Issue: 2
Author(s): Deeksha Manchanda, Manish Makhija, Parijat Pandey and Manu Sharma*
Affiliation:
- Department of Pharmacy, Banasthali Vidyapith University, Rajasthan - 304022, India
Keywords:
Transfersomes, ultra-deformability, flexibility, phospholipids, edge activator, applications.
Abstract: A feasible nano transdermal delivery system generally intends to have specific ideal
and distinct characteristics primarily for safety, clinical efficacy, and boosted therapeutic index.
The delivery of drugs, particularly macromolecules, across the skin is one of the most strenuous
obstacles in front of pharmaceutical scientists. Technology advancement has provided some opportunities
to overcome this difficulty by utilising microneedle arrays, ablation, laser methods etc.
However, associated uneasiness, painful sensation, and higher cost of therapies limit their day-today
use. Therefore, researchers have focused on developing alternate carriers like ultra-deformable
liposomes, also termed transfersomes. Transfersomes are composed of a lipid bilayer
containing phospholipids and an edge activator to facilitate drug delivery via transdermal route to
deeper layers of skin and for higher systemic bioavailability. The bilayer structure of transfersomes
allows ease of encapsulation of both hydrophilic and lipophilic drugs with higher permeability
than typical liposomes. Therefore, among various vesicular systems, transfersomes have developed
much interest in targeted and sustained drug delivery. The current review primarily emphasizes
critical aspects of transfersomes, including their applications, clinical trial studies, and patents
found in various literature sources.
