Title:Natural Phenolic Compounds with Antithrombotic and Antiplatelet
Effects: A Drug-likeness Approach
Volume: 31
Issue: 26
Author(s): Diégina Araújo Fernandes, Ayala Nara Pereira Gomes, Camila Macaubas da Silva, Isabelly Soares de Medeiros Henriques, Renata Priscila Barros de Menezes, Marcus Tullius Scotti, Yanna Carolina Ferreira Teles, RuAngelie Edrada-Ebel and Maria de Fatima Vanderlei de Souza*
Affiliation:
- Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraiba,
João Pessoa, Brazil
- Post Graduation Program in Development and Technological Innovation in
Medicines, Federal University of Paraiba, João Pessoa, Brazil
Keywords:
Phenolic compounds, anticoagulant, antiplatelet, antithrombotic, drug-likeness, bioinformatics.
Abstract:
Background: Thrombosis is one of the major causes of morbidity and mortality
in a wide range of vessel diseases. Several studies have been conducted to identify antithrombotic
agents from medicinal plants, and phenolic compounds (PCs) have been
shown to effectively inhibit plasma coagulation and platelet aggregation.
Objectives: This study aimed to conduct a survey of the natural PCs with proven antithrombotic
and antiplatelet activities, as well as to evaluate by computational modeling
the physicochemical and toxicological properties of these compounds using drug-likeness
approaches.
Methods: The data were collected from the scientific database: ‘Web of Science’,
‘Scifinder’, ‘Pubmed’, ‘ScienceDirect’ and ‘Google Scholar’, the different classes of
PCs with antithrombotic or antiplatelet effects were used as keywords. These molecules
were also evaluated for their Drug-Likeness properties and toxicity to verify their profile
for being candidates for new antithrombotic drugs.
Results: In this review, it was possible to register 85 lignans, 73 flavonoids, 28 coumarins,
21 quinones, 23 phenolic acids, 8 xanthones and 8 simple phenols. Activity records
for tannins were not found in the researched databases. Of these 246 compounds,
213 did not violate any of Lipinski's rules of five, of which 125 (59%) showed non-toxicity,
being promising candidates for new potential antithrombotic drugs.
Conclusion: This review arouses interest in the isolation of phenolic compounds that
may allow a new approach for the prevention of both arterial and venous thrombosis,
with the potential to become alternatives in the prevention and treatment of cardiovascular
diseases.
