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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

NADPH氧化酶2 (NOX2)与肿瘤耐药的关系

卷 24, 期 12, 2024

发表于: 15 February, 2024

页: [1195 - 1212] 页: 18

弟呕挨: 10.2174/0115680096277328240110062433

价格: $65

摘要

NADPH氧化酶作为细胞内活性氧(ROS)的主要来源，在机体的免疫反应和氧化应激反应中起着重要作用。NADPH氧化酶2 (NADPH oxidase 2, NOX2)是NADPH氧化酶家族中第一个也是最具代表性的成员，其在肿瘤细胞发育中的作用越来越受到人们的关注。我们之前的研究表明，NOX2的关键亚基p40phox中的NCF4多态性影响了弥漫性大B细胞淋巴瘤患者使用利美昔单抗治疗的结果。假设NOX2介导的ROS可增强某些抗肿瘤药物的细胞毒作用，有利于肿瘤患者。一些文献综述了NOX2及其同源物介导的ROS在抗肿瘤治疗中的作用，但很少有研究关注NOX2的表达与抗肿瘤耐药之间的关系。本文系统介绍了以NOX2为代表的氮氧化物家族，并对最新的NOX2抑制剂和激动剂进行了分类。这将有助于研究者更加理性、客观地认识NOX2在肿瘤耐药中的双重作用，并有望为肿瘤治疗和克服肿瘤耐药提供新的思路。

关键词: 活性氧，NADPH氧化酶2，癌症药物开发，耐药性，癌症，肿瘤

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