Title:Sagittal Abdominal Diameter as the Best Predictor of Metabolic
Syndrome in HIV-Infected Men on Antiretroviral Therapy
Volume: 22
Issue: 2
Author(s): Zorka Drvendžija*, Biljana Srdić Galić, Miloš Vujanović, Daniela Marić, Nina Brkić Jovanović, Snežana Brkić, Vesna Turkulov and Dalibor Ilić
Affiliation:
- Department of Anatomy, Medical Faculty, University of Novi Sad, Novi Sad, Serbia
Keywords:
Anthropometry, antiretroviral therapy, cardiovascular risk, HIV-infected men, metabolic syndrome, HIV.
Abstract:
Background: The interaction of human immunodeficiency virus (HIV), host and antiretroviral
therapy (ART) causes a range of metabolic disorders that can be characterized as a
metabolic syndrome (MetS) that increases the cardiovascular risk. MetS involves central obesity,
which can be detected using different anthropometric parameters.
Objective: To assess the abilities of different anthropometric parameters in the prediction of MetS
in HIV-infected men on ART.
Method: The study involved 92 male participants (mean age 44.46±10.38 years), divided into two
groups: with and without MetS. All subjects underwent biochemical evaluation (triglycerides,
HDL-cholesterol, fasting glucose), blood pressure measurement and anthropometric assessment:
body mass, body height, body mass index (BMI), body fat mass, body circumferences (chest, upper
arm, forearm, waist, hip, proximal and middle thigh and calf), sagittal abdominal diameter
(SAD), skinfold thicknesses (subscapular, anterior and posterior upper arm, anterior and lateral
forearm, abdominal, supraspinal, thigh and calf), waist-to-hip ratio (WHR), waist-to-height ratio
(WHtR), waist-to-thigh ratio (WTR), sagittal abdominal diameter–to-body height ratio (SADH),
body adiposity index (BAI) and conicity index. MetS was specified according to IDF criteria.
Results: Subjects with MetS had statistically significant higher values of all anthropometric parameters
except middle thigh circumference, calf skinfold and body height. According to ROC
analysis and Binary Logistic Regression, SAD has been shown as the best predictor of MetS with
a predictive value of 21.40 cm (AUC:0.91), followed by WHR with a predictive value of 0.93.
Conclusion: Sagittal abdominal diameter is the strongest anthropometric indicator of MetS in
HIV-infected patients on ART.
