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Current Cancer Drug Targets

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Research Article

Vitamin B12 Protects against Genotoxicity Induced by Cisplatin

Author(s): Wejdan M. Al-Bataineh, Karem H. Alzoubi*, Omar F. Khabour, Amjad Mahasneh and Enaam M. Al Momany

Volume 24, Issue 11, 2024

Published on: 30 January, 2024

Page: [1169 - 1176] Pages: 8

DOI: 10.2174/0115680096284684240110044954

Price: $65

Open Access Journals Promotions 2
Abstract

Background: Cisplatin is an effective synthetic chemotherapeutic drug used for cancer treatment. Vitamin B12 has been shown to possess anti-genotoxic activity. This study aimed to investigate the effect of vitamin B12 on chromosomal damage induced by cisplatin.

Methods: The level of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) were measured in cultured human blood lymphocytes treated with cisplatin and/or vitamin B12.

Results: The results showed a significantly elevated frequency of CAs and SCEs of cisplatin-treated cultures compared to the control (P < 0.05). The CAs and SCEs induced by cisplatin were significantly lowered by pretreatment of cell cultures with vitamin B12. In addition, cisplatin caused a slight reduction in the mitotic index (MI), while vitamin B12 did not modulate the effect of cisplatin on MI.

Conclusion: Vitamin B12 can protect human lymphocytes against genotoxicity associated with cisplatin.

Keywords: Vitamin B12, cisplatin, sister chromatid exchanges, chromosomal aberrations, mitotic index, genotoxicity.

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