Title:Investigating the Relationship between COVID-19 In-hospital Death and
Acute Kidney Injury
Volume: 5
Issue: 4
Author(s): Ramin Haghighi, Nikoo Fereyduny, Mohammad Bagher Oghazian, Ashkan Haghighi, Amir Bigdeli*Amirhossein Sahebkar*
Affiliation:
- Department of
Nephrology and Hypertension, Sayad Shirazi Hospital, Faculty of Medicine, Golestan University of Medical Sciences,
Gorgan, Iran
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical
Sciences, Mashhad, Iran
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad,
Iran
- School of Medicine, The University of Western Australia, Perth, Australia
- Department of Biotechnology, School
of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Acute kidney injury, COVID-19, mortality, proteinuria, hematuria.
Abstract:
Introduction: Coronavirus Disease 2019 (COVID-19) can induce multiorgan failure, including
acute kidney injury (AKI), which is associated with a poor prognosis. Some of these patients
develop proteinuria, hematuria, and elevated serum creatinine, therefore some require hemodialysis.
This study aimed to investigate the association between in-hospital death due to COVID-19 and the
prevalence of AKI.
Methods: In a retrospective study, the available data of patients who died because of COVID-19
from April 1 to September 22, 2020 in a referral hospital was investigated using the case census
method.
Results: A total of 190 patients who died of COVID-19 were evaluated. Of these, 111 (58.42%) had
AKI, with 108 (56.84%) being male. The mean age of the subjects was 66.16±15.43 years old. The
mean time from hospital admission to death was about 9 days in all patients. Although not statistically
significant, the findings showed that patients who developed AKI died sooner. The most frequent
underlying diseases were hypertension [n= 101 (53.16%)] and diabetes [n= 44 (23.16%)]. Moreover,
a higher proportion of subjects with AKI as compared to those without AKI were admitted to
the intensive care unit (ICU), and had abnormal proteinuria profile (p-value=0.045 and 0.025, respectively).
Conclusion: The prevalence of AKI was 58.42% in patients who died from COVID-19 disease.
Moreover, abnormal proteinuria and ICU admission were significantly higher in COVID-19 patients
with AKI than in those without AKI.
