Title:Targeted Cancer Stem Cell Therapeutics: An Update
Volume: 24
Author(s): Naurin Fatima, Mohammad Umar, Subiya Ambreen, Mohd Shaququzzaman, Mohammad Mumtaz Alam and Ruhi Ali*
Affiliation:
- Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India
Keywords:
Cancer stem cells, Self renewal, Tumor microenvironment, MicroRNAs, Epithelial-mesenchymal transition, Targeted therapy.
Abstract: Cancer stem cells (CSCs) have become a key player in the growth of tumors, the spread
of cancer, and the resistance to therapeutic interventions. Targeting these elusive cell populations
has the potential to fundamentally alter cancer treatment plans. CSCs, also known as tumor-initiating
cells (TICs), are thought to play a role in both medication resistance and cancer recurrence.
This is explained by their capacity to regenerate themselves and change into different kinds of cancer
cells. Due to their higher expression of ATP-binding cassette (ABC) membrane transporters,
enhanced epithelial to mesenchymal (EMT) characteristics, improved immune evasion, activation
of survival signaling pathways, and improved DNA repair mechanisms, CSCs exhibit extraordinary
resistance to therapies. This comprehensive analysis delves into advancements in the domain
of Targeted Cancer Stem Cell Therapeutics, concentrating on unraveling the distinctive traits of
CSCs and the therapeutic methods devised to eliminate them.
