Title:Anticancer Properties of Baicalin against Breast Cancer and other
Gynecological Cancers: Therapeutic Opportunities based on Underlying
Mechanisms
Volume: 17
Author(s): Mohammad Hossein Pourhanifeh, Hossein Farrokhi-Kebria, Parsa Mostanadi, Tahereh Farkhondeh and Saeed Samarghandian*
Affiliation:
- Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran
Keywords:
Baicalin, Ovarian cancer, Endometrial cancer, Breast cancer, Cervical cancer, MAPK/ERK.
Abstract: Gynecological cancers are serious life-threatening diseases responsible for high morbidity and mortality around the world. Chemotherapy,
radiotherapy, and surgery are considered standard therapeutic modalities for these cancers. Since the mentioned treatments have undesirable side
effects and are not effective enough, further attempts are required to explore potent complementary and/or alternative treatments. This study was
designed to review and discuss the anticancer potentials of baicalin against gynecological cancers based on causal mechanisms and underlying
pathways. Traditional medicine has been used for thousands of years in the therapy of diverse human diseases. The therapeutic effects of natural
compounds like baicalin have been widely investigated in cancer therapy. Baicalin was effective against gynecological cancers by regulating key
cellular mechanisms, including apoptosis, autophagy, and angiogenesis. Baicalin exerted its anticancer property by regulating most molecular
signaling pathways, including PI3K/Akt/mTOR, NFκB, MAPK/ERK, and Wnt/β-catenin. However, more numerous experimental and clinical
studies should be designed to find the efficacy of baicalin and the related mechanisms of action.
