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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

外泌体分析在卵巢癌治疗中的应用进展

卷 24, 期 9, 2024

发表于: 25 January, 2024

页: [920 - 929] 页: 10

弟呕挨: 10.2174/0115680096281906231213055422

价格: $65

Open Access Journals Promotions 2
摘要

外泌体是非常小的(纳米级)囊泡，通过参与生物成分转移介导的细胞间通讯参与肿瘤的发展。外泌体似乎在各种癌症的发展中起着至关重要的作用，例如卵巢癌，一种常见的女性恶性肿瘤。据报道，卵巢癌的几个特征受到外泌体介导的细胞串扰的影响，包括调节腹膜播散和化疗耐药。由于一些生物分子，如miRNAs和mRNA的表达在卵巢癌中发生了变化，这些外显生物分子可以作为预后、诊断和治疗的生物标志物。此外，选择性地将特定的化疗药物装载到外泌体中突出了这些生物载体作为潜在的递送装置。外泌体可以人工提供和改造，以更好地靶向卵巢癌的感兴趣的部位。在本文中，我们总结了外泌体在卵巢癌治疗中应用的显著成果，以获得适用于卵巢癌的过渡性见解。

关键词: 卵巢癌，外泌体，生物活性分子，生物标志物，运载工具，细胞外囊泡。

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