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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Case Report

Novel Association of RAD54L Mutation with Müllerian Clear Cell Carcinoma of the Male Urethra: New Insights Regarding the Molecular Mechanisms of a Rare Tumour

Author(s): Huiyan Deng, Yan Ding, Zhiyu Wang, Xiangdong Liang and Yueping Liu*

Volume 24, Issue 10, 2024

Published on: 25 January, 2024

Page: [1080 - 1087] Pages: 8

DOI: 10.2174/0115680096260943231212043820

Price: $65

Abstract

Introduction: Müllerian clear cell carcinoma of the male urethra is similar to that of the female genital tract in terms of morphology and immunohistochemical expression but is rarely observed in clinical practice.

Case Presentation: Here, we report the case of a 65-year-old man diagnosed with Müllerian clear cell carcinoma who harboured a mutation in RAD54L. This patient was diagnosed by electrocautery and ultimately underwent prostatectomy. After a six-month follow-up period, no signs of recurrence or additional malignancy were found. Based on our analysis of the available literature, it appears that Müllerian clear cell carcinoma with RAD54L mutation has not been reported until now.

Conclusion: This case enhances our knowledge of the molecular biology of Müllerian clear cell carcinoma of the male urethra, which will help clinicians select optimal treatment options for this rare cancer in patients with specific driver mutations.

Keywords: Müllerian clear cell carcinoma, RAD54L gene, male urethra, next-generation sequencing, treatment, prognosis.

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