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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Systematic Review Article

磷脂酰肌醇3-激酶抑制剂对乳腺癌患者的疗效和安全性:随机对照试验的系统评价和meta分析

卷 24, 期 9, 2024

发表于: 24 January, 2024

页: [941 - 951] 页: 11

弟呕挨: 10.2174/0115680096266181231207110048

价格: $65

Open Access Journals Promotions 2
摘要

背景:磷脂酰肌醇3-激酶(PI3K)抑制剂属于抑制PI3K蛋白活性的一类药物,PI3K蛋白在乳腺癌细胞中通常过表达。然而,有必要总结证据,为乳腺癌患者使用PI3K抑制剂的益处提供结论性建议。因此,本综述评估了PI3K抑制剂在乳腺癌患者中的有效性和安全性。 方法:检索在PubMed Central、EMBASE、MEDLINE、SCOPUS、Central、WHO试验注册和Clinicaltrials.gov中进行,截止到2022年12月。采用随机效应模型进行meta分析。合并风险比(HR)/风险比(RR)以95%置信区间(ci)报告。 结果:总共有13项研究被纳入分析。大多数是多国研究,有较高的偏倚风险。在疗效参数方面,无进展生存期的合并危险度为0.79 (95%CI: 0.67-0.92),完全缓解的合并危险度为1.54 [95%CI: 1.14 - 2.09],部分缓解的合并危险度为1.18 [95%CI: 0.87-1.61],总缓解的合并危险度为1.20 [95%CI: 0.93-1.56],病情稳定的合并危险度为1.09 [95%CI: 0.78-1.53],病情进展的合并危险度为0.80 [95%CI: 0.74 - 0.87],临床获益为1.08 [95%CI: 0.80-1.49]。对于安全性参数,高血糖的合并RR为4.57 [95%CI: 3.15-6.62],胃肠道毒性的合并RR为1.82 [95%CI: 1.56 - 2.14]。 结论:对于乳腺癌患者,尤其是PIK3CA突变患者,PI3K抑制剂的疗效优于目前关注的标准。因此,临床医生和肿瘤学家可以为目标人群提供这种药物,但对糖尿病患者要格外小心。

关键词: 乳腺癌,荟萃分析,磷脂酰肌醇3激酶抑制剂,系统评价,总生存期,无进展生存期。

图形摘要
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