Treatment Advances in Lung Cancer with Leptomeningeal Metastasis

Yuan      Meng; Meiying      Zhu; Jie      Yang; Xuerui      Wang; Yangyueying      Liang; Minghui      Yu; Longhui      Li; Fanming      Kong
doi:10.2174/0115680096276133231201061114
Abstract

Leptomeningeal metastasis (LM) is a serious and often fatal complication in patients with advanced lung cancer, resulting in significant neurological deficits, decreased quality of life, and a poor prognosis.
This article summarizes current research advances in treating lung cancer with meningeal metastases, discusses clinical challenges, and explores treatment strategies.
Through an extensive review of relevant clinical trial reports and screening of recent conference abstracts, we collected clinical data on treating patients with lung cancer with meningeal metastases to provide an overview of the current research progress.
Exciting progress has been made by focusing on specific mutations within lung cancer, including the use of EGFR tyrosine kinase inhibitors or inhibitors for anaplastic lymphoma kinase gene rearrangement, such as osimertinib, alectinib, and lorlatinib. These targeted therapies have shown impressive results in penetrating the central nervous system (CNS). Regarding whole-brain radiotherapy, there is currently some controversy among investigators regarding its effect on survival. Additionally, immune checkpoint inhibitors (ICIs) have demonstrated reliable clinical benefits due to their ability to retain anticancer activity in CNS metastases. Moreover, combination therapy shows promise in providing further treatment possibilities.
Considerable progress has been made in the clinical research of lung cancer with LM. However, the sample size of prospective clinical trials investigating LM for lung cancer is still limited, with most reports being retrospective. Developing more effective management protocols for metastatic LM in lung cancer remains an ongoing challenge for the future.
Keywords: Leptomeningeal metastasis, lung cancer, treatment advances, targeted therapy, immunotherapy, radiotherapy.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/0115680096276133231201061114	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
Current Cancer Drug Targets

Treatment Advances in Lung Cancer with Leptomeningeal Metastasis

Abstract

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Innovative Cancer Drug Targets: A New Horizon in Oncology

The Impact of Cancer Neuroscience on Novel Brain Cancer Treatment

Unraveling the Tumor Microenvironment and Potential Therapeutic Targets: Insights from Single-Cell Sequencing and Spatial Transcriptomics

Current Cancer Drug Targets

Treatment Advances in Lung Cancer with Leptomeningeal Metastasis

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Innovative Cancer Drug Targets: A New Horizon in Oncology

The Impact of Cancer Neuroscience on Novel Brain Cancer Treatment

Unraveling the Tumor Microenvironment and Potential Therapeutic Targets: Insights from Single-Cell Sequencing and Spatial Transcriptomics

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