Insights into Prospects of Novel NSAID Prodrugs in the Management of
Gastrointestinal Toxicity: A Perspective Review

Rajat      Goyal; Sumeet      Gupta; Prabodh      Sharma; Manu      Sharma

doi:10.2174/0127722708278736231205055035

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have a long history in the healthcare system due to their therapeutic potential. These NSAIDs cause ulcerogenicity, stomach pains, gastrointestinal hemorrhage, mucosa bleeding, and pancreatitis when used moderately and consistently. With researchers, managing the aforementioned adverse effects therapeutically is getting increasingly difficult. One method for creating NSAID moieties with low penetration as well as ulcerogenic properties is the prodrug technique. During the oral consumption of NSAID-prodrugs, ulcerations, intestinal hemorrhage, and mucosa hemorrhage have significantly decreased. Considering this background, this review focussed on NSAID prodrugs as well as their justifications, the pathogenesis of NSAIDs inducing gastrointestinal toxicity, and the role of different antioxidants and spacer groups. Prodrug moieties have more advantages over parent medicines concerning both solubility and lipophilicity. In general, NSAID-class prodrugs can successfully treat both acute and long-term inflammation and aches without causing ulcerotoxicity and related gastrointestinal side effects, which reduces their burden from the pharmacoeconomic perspective.

Keywords: Prodrugs, NSAIDs, antioxidants, gastrointestinal toxicity, oxidative stress, gastroduodenal damage.

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DOI https://dx.doi.org/10.2174/0127722708278736231205055035	Print ISSN 2772-2708
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