Title:Generalized Analysis of Open Genetic Databases Reveals New
Associations with Migraine
Volume: 20
Issue: 3
Author(s): Aliya Yakubova*Albert A. Rizvanov
Affiliation:
- Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia
Keywords:
Migraine, genetic database, polymorphism, genetic variant, genetic marker, regulatory proteins.
Abstract:
Background: Migraine is one of the most common diseases that significantly
impairs the quality of life. This condition has a pronounced genetic component. Genes responsible
for the development of monogenic forms of hemiplegic migraine have already
been identified, and the search for genetic associations with common migraine and its
subtypes continues.
Objective: The aim of this study was to search for new potential genetic markers of migraine
by analyzing available open genetic databases.
Methods: The analysis included databases such as ClinVar, GWAS Catalog, UK Biobank
and FinnGen. In all databases, the keyword "migraine" was used to search for migraineassociated
variants. Genetic variants with clinical annotations "pathogenic" and "likely
pathogenic" were selected from the variants in the ClinVar database. From other databases,
variants with an association significance level of p ≤ 5×10-8 were chosen.
Results: A total of 112 genetic variants associated with migraine were identified. After
excluding polymorphisms known from previous migraine studies, it was found that 45
genetic variants were identified for the first time.
Conclusion: These variants belong to various functional groups, including ion channels,
enzymes, receptors, and regulatory proteins, confirming the current understanding of the
polygenic nature of migraine. Identifying new genetic associations with migraine can
contribute to a better understanding of its pathogenesis and open new possibilities for diagnosis
and the development of more effective treatment strategies for this condition.
