Title:Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders
Volume: 27
Issue: 14
Author(s): Sonia Singh*, Ashima Ahuja and Shilpi Pathak
Affiliation:
- Institute of Pharmaceutical Research, GLA University Mathura, U.P, 281406, India
Keywords:
Neurodegeneration, alzheimer's disease, antioxidant therapy, reactive oxygen species, inflammatory responses, patient compliance, oxidative stress, free radicals, Parkinson's disease.
Abstract: Neurodegeneration causes premature death in the peripheral and central nervous system.
Neurodegeneration leads to the accumulation of oxidative stress, inflammatory responses,
and the generation of free radicals responsible for nervous disorders like amyotrophic lateral
sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders. Therefore, focus
must be diverted towards treating and managing these disorders, as it is very challenging. Furthermore,
effective therapies are also lacking, so the growing interest of the global market must
be inclined towards developing newer therapeutic approaches that can intercept the progression
of neurodegeneration. Emerging evidences of research findings suggest that antioxidant therapy
has significant potential in modulating disease phenotypes. This makes them promising candidates
for further investigation. This review focuses on the role of oxidative stress and reactive
oxygen species in the pathological mechanisms of various neurodegenerative diseases, amyotrophic
lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disorders and
their neuroprotection. Additionally, it highlights the potential of antioxidant-based therapeutics
in mitigating disease severity in humans and improving patient compliance. Ongoing extensive
global research further sheds light on exploring new therapeutic targets for a deeper understanding
of disease mechanisms in the field of medicine and biology targeting neurogenerative disorders.
