Title:Investigating the Influence of Gut Microbiota-related Metabolites in
Gastrointestinal Cancer
Volume: 24
Issue: 6
关键词:
微生物衍生代谢物，胃肠道癌症，双重作用，肠道微生物群，肠道微生物群失调，代谢物产生。
摘要: Gastrointestinal (GI) cancer is a major health concern due to its prevalence, impact on
well-being, high mortality rate, economic burden, and potential for prevention and early detection.
GI cancer research has made remarkable strides in understanding biology, risk factors, and treatment
options. An emerging area of research is the gut microbiome's role in GI cancer development
and treatment response. The gut microbiome, vital for digestion, metabolism, and immune
function, is increasingly linked to GI cancers. Dysbiosis and alterations in gut microbe composition
may contribute to cancer development. Scientists study how specific bacteria or microbial
metabolites influence cancer progression and treatment response. Modulating the gut microbiota
shows promise in enhancing treatment efficacy and preventing GI cancers. Gut microbiota dysbiosis
can impact GI cancer through inflammation, metabolite production, genotoxicity, and immune
modulation. Microbes produce metabolites like short-chain fatty acids, bile acids, and secondary
metabolites. These affect host cells, influencing processes like cell proliferation, apoptosis, DNA
damage, and immune regulation, all implicated in cancer development. This review explores the
latest research on gut microbiota metabolites and their molecular mechanisms in GI cancers. The
hope is that this attempt will help in conducting other relevant research to unravel the precise
mechanism involved, identify microbial signatures associated with GI cancer, and develop targets.
