Title:The Levels of Phoenixin-14 and Phoenixin-20 in Patients with Type 2
Diabetes Mellitus
Volume: 24
Issue: 11
Author(s): Ummugulsum Can*, Sadinaz Akdu and Serdar Şahinoğlu
Affiliation:
- Konya City Hospital, Department of Biochemistry, Konya, Turkey
Keywords:
Type 2 diabetes mellitus, phoenixin-14, insulin resistance, inflammation, food regulation, phoenixin-20.
Abstract:
Background: New pathogenesis-related early detection markers are needed to prevent
Type 2 Diabetes Mellitus (T2DM).
Objective: We aimed to determine phoenixin (PNX)-14 and PNX-20 levels in T2DM patients
and investigate their relationship with diabetes.
Methods: 36 T2DM patients and 36 healthy controls were included in the study, and PNX-14
and PNX-20 levels in blood samples taken from the groups were measured by ELISA method.
Results: Patients' serum PNX-14 and PNX-20 levels were statistically significantly lower than
in controls (p <0.001). A negative correlation was detected between PNX-14 and BMI, fasting
blood sugar, HbA1c%, and HOMA-IR. A negative correlation was found between PNX-20 and
BMI, fasting insulin and glucose, HbA1c%, and HO-MA-IR. A positive correlation was noticed
between PNX-14 and PNX-20 levels. In ROC analyses, PNX-14 and PNX-20 performed almost
equally in predicting T2DM. In predicting T2DM, the area under the ROC curve for PNX-14
was 0.874 (cutoff value 413.4 ng/L, sensitivity 89 %, specificity 72%), and for PNX-20 was
0.858 (cutoff value 228.7 ng/L, sensitivity 80 %, specificity 83 %).
Conclusion: This study shows that serum PNX measurement may have a high level of evidence
in predicting T2DM. PNX, related to pathogenesis, may be useful in diagnosing T2DM and other
information to support clinical decision-making.
