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Research Article

Effects of Standardized Aqueous Ethanolic Extract of Leaves of Ficus Deltoidea var. Trengganuensis on Blood Pressure in Spontaneously Hypertensive Rats

Author(s): Zurain Radjeni, Mardiana Abdul Aziz, Norasikin Ab Azis, Mohd Saleh Ahmad Kamal and Harbindar Jeet Singh*

Volume 14, Issue 5, 2024

Published on: 09 January, 2024

Article ID: e090124225438 Pages: 11

DOI: 10.2174/0122103155281988231211105638

Price: $65

Abstract

Background: Laboratory evidence pertaining to the antihypertensive activity of a number of Ficus deltoidea (FD) varieties remains undetermined, although extracts of some of these varieties have been shown to have angiotensin-converting enzyme (ACE) inhibitory activity in vitro.

Objective: This study, therefore, evaluated the effect of a standardized aqueous-ethanolic extract of leaves of Ficus deltoidea var. trengganuensis (FDT) on blood pressure in spontaneously hypertensive rats (SHR).

Methods: SHR were given either 800, 1000 or 1200 mg kg-1 body weight of standardized aqueousethanolic extract of FDT or 10 mg kg-1 body weight of losartan or 0.5 ml of distilled water daily for four weeks.

Results: SBP decreased significantly in FDT- and losartan-treated rats (p < 0.05). Components of RAAS and other serum and urinary parameters were not different between the groups except for endothelin-1, which was significantly lower than that in the controls. Urinary calcium excretion was significantly higher in FDT-treated rats (p < 0.05).

Conclusion: It seems that daily oral administration of FDT significantly lowers blood pressure in SHR through mechanisms that do not involve RAAS but may involve the endothelium or other yetto- be-determined mechanisms.

Keywords: Ficus deltoidea var. trengganuensis, RAAS, eNOS, ET-1, blood pressure, spontaneously hypertensive rats.

Graphical Abstract

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