Pharmacological Investigation of Anticonvulsant Effect of Artemisia Vulgaris on Pentylenetetrazole-Induced Epileptic Seizures in Zebrafish Experimental Model

Mahima      Sharma; Godlaveti   Vijay Narasimha   Kumar; Pankaj      Gupta

doi:10.2174/0115748855268042231130041958

Abstract

Background: Epilepsy is the most common neurological disorder, characterized by abnormal, unpredictable, and recurrent seizures. In the alternative medicine system, Artemisia vulgaris has been used to treat epileptic symptoms since its inception. However, scientific evidence concerning its effect on the treatment of epileptic seizures is not available.

Objectives: The objective of the study is to evaluate the anti-convulsant potential of Artemisia vulgaris in zebrafish experimental models.

Methods: Zebrafish larvae and adult zebrafish were used as experimental models. Briefly, larvae and adult zebrafish were exposed to 0.5% of the test medicine Artemisia vulgaris mother tincture (ϕ) and its potencies (6 CH, 30 CH), and valproic acid for 1 hour. After 1 hour of exposure, they were exposed to pentylenetetrazole to record different seizure scores from 1 to 5 using ANY maze video tracking software.

Results: Artemisia vulgaris 30CH in zebrafish larvae and Artemisia vulgaris 6 CH and 30 CH in adult zebrafish delayed the latency score from score 1 to score 5 and were found effective against PTZinduced locomotor activity and seizure duration and intensity.

Conclusion: In conclusion, Artemisia vulgaris (6 CH and 30 CH) has the potential to be a novel treatment for symptomatic epileptic seizures and could be a potential alternative drug candidate for symptomatic treatment of epilepsy.

Keywords: Convulsion, epilepsy, danio rerio, alternative therapy, larvae, anti-convulsant.

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DOI https://dx.doi.org/10.2174/0115748855268042231130041958	Print ISSN 1574-8855
Publisher Name Bentham Science Publisher	Online ISSN 2212-3903

Current Drug Therapy

Pharmacological Investigation of Anticonvulsant Effect of Artemisia Vulgaris on Pentylenetetrazole-Induced Epileptic Seizures in Zebrafish Experimental Model

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