Title:Role of Amphotericin B in the Treatment of Mucormycosis
Volume: 30
Issue: 1
Author(s): Alisha Sachdeva, Monika Targhotra, Meenakshi Kanwar Chauhan*Monica Chopra
Affiliation:
- NDDS Research Laboratory, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical
Sciences and Research University, Pushp Vihar Sec-3, MB Road, New Delhi 110017, India
Keywords:
Mucormycosis, lipid formulation, amphotericin B (AMB), fungal infection, antifungal agents, sinusitis.
Abstract:
Background: Regardless of the most recent inclusion of mold-active agents (isavuconazole and
posaconazole) to antifungal agents against mucormycosis, in conjunction with amphotericin B (AMB) items,
numerous uncertainties still exist regarding the treatment of this rare infection. The order Mucorales contains a
variety of fungi that cause the serious but uncommon fungal illness known as mucormycosis. The moulds are
prevalent in nature and typically do not pose significant risks to people. Immunocompromised people are affected
by it.
Objective: This article's primary goal is to highlight the integral role that AMB plays in this condition.
Methods : Like sinusitis (including pansinusitis, rhino-orbital, or rhino-cerebral sinusitis) is one of the many
signs and symptoms of mucormycosis. The National Center for Biotechnology Information (NCBI) produces a
variety of online information resources for review articles on the topic-based mucormycosis, AMB, diagnosis
of mucormycosis and the PubMed® database of citations and abstracts published in life science journals. These
resources can be accessed through the NCBI home page at https://www.ncbi.nlm.nih.gov.
Results: The article provides a summary of the pharmacological attributes of the various AMB compositions
accessible for systemic use.
Conclusion: The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability,
and other features, and illustrates their most useful characteristics for clinical application.
