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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Current Insight into Novel Delivery Approaches of Resveratrol for Improving Therapeutic Efficacy and Bioavailability with its Clinical Updates

Author(s): Ranjit K. Harwansh*, Paras Yadav and Rohitas Deshmukh

Volume 29, Issue 37, 2023

Published on: 05 December, 2023

Page: [2921 - 2939] Pages: 19

DOI: 10.2174/0113816128282713231129094715

Price: $65

Abstract

Resveratrol (RSV) is a polyphenolic phytoalexin, and belongs to the stilbene family. RSV has several therapeutic activities such as cardioprotective, anticancer, and antioxidant. Apart from its therapeutic benefits, its pharmacological uses are limited due to low solubility, poor bioavailability, and short biological halflife. A researcher continuously focuses on overcoming the limitations of RSV through nanotechnology platforms to get the optimum health benefits. In this context, nanocarriers are pioneering to overcome these drawbacks. Nanocarriers possess high drug loading capacity, thermal stability, low production cost, longer shelflife, etc. Fortunately, scientists were proficient in delivering resveratrol-based nanocarriers in the present scenario. Nanocarriers can deliver drugs to the target sites without compromising the bioavailability. Thus, this review highlights how the latest nanocarrier systems overcome the shortcomings of RSV, which will be good for improving therapeutic efficacy and bioavailability. Moreover, recent updates on resveratrol-based novel formulations and their clinical trials have been addressed to manage several health-related problems.

Keywords: Resveratrol, polyphenolic, nanocarriers, herbal bioactive, bioavailability, half-life.

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