Title:Infusion of Magnetic Nanocatalyst to Microwave Propped Synthesis of
Bioactive Azaheterocycles
Volume: 10
Issue: 2
Author(s): Pranali Hadole, Sampat Shingda, Aniruddha Mondal, Kundan Lal, Ratiram G. Chaudhary and Sudip Mondal*
Affiliation:
- PG Department of Chemistry, Seth Kesarimal Porwal College of Arts & Science & Commerce, Kamptee, 441001, India
Keywords:
Microwave-assisted, azaheterocyclic, green route, magnetic nanocatalyst, synthetic methodologies.
Abstract: Microwave-assisted synthesis is a powerful tool in organic chemistry, providing a
rapid and efficient method for the synthesis of bioactive heterocycles. The application of microwaves
significantly reduces reaction times and increases percentage yields with high purity of the
final product. To make the synthetic protocol greener, the application of the magnetic nanocatalyst
is a rapidly growing area of interest nowadays. Magnetic nanocatalyst, with its unique features
like magnetic separable facile recovery from the reaction media heterogeneously, makes the
overall synthetic strategy cleaner, faster, and cost-effective. Aiming this, in the present review,
we will focus on the infusion of Magnetic nanocatalyst to microwave-assisted synthesis of various
classes of azaheterocyclic compounds, including pyridines, pyrimidines, quinolines, and benzimidazoles.
The synthetic methodologies involved in the preparation of these heterocycles are
highlighted, along with their biological activities. Furthermore, in this review, the most recent
and advanced strategies to incorporate nanocatalysts in the microwave-assisted synthesis of natural
products containing azaheterocyclic moieties in drug discovery programs are elucidated in
detail, along with the incoming future scope and challenges.