The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical
Cancer

Sajad      Najafi; Farhoodeh      Ghaedrahmati; Mahrokh      Abouali Gale Dari; Maryam      Farzaneh; Razieh      Mohammad Jafari
doi:10.2174/0115743624273536231105142321
Abstract

Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease influenced by various genetic, epigenetic, and environmental factors. While treatment options such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs (circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells, making them a promising biomarker for diagnosis and treatment. This review provides an overview of the functional roles of circRNAs in the context of cervical cancer.
Keywords: ncRNAs, circRNAs, cervical cancer, pathogenesis, diagnosis, biomarker.
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DOI https://dx.doi.org/10.2174/0115743624273536231105142321	Print ISSN 1574-3624
Publisher Name Bentham Science Publisher	Online ISSN 2212-389X
Current Signal Transduction Therapy

The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical Cancer

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