Title:Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early
Diagnosis
Volume: 24
Issue: 8
Author(s): Bai-Yi Liu, Dan Zhang, Zhu Fan, Jing-Jing Jin, Cai-Hong Li, Rui-Nan Guo, Xue-Juan Li and Yan Huang*
Affiliation:
- Department of Respiratory, The Affiliated Hospital of North China University of Science and Technology, Hebei 063000, China
Keywords:
Inflammation, lung infection, metagenomic sequencing, type 2 diabetes mellitus, early clinical diagnosis, C-reactive protein.
Abstract:
Objective: To study the etiological characteristics of community-acquired pneumonia
(CAP) combined with type 2 diabetes (T2D), providing a reference for early clinical diagnosis
and treatment of the disease.
Methods: We selected a total of 93 patients with CAP and analyzed their metagenomics nextgeneration
sequencing (mNGS) data. The case group comprised 46 patients with combined
CAP/T2D, and the control group comprised 47 patients without diabetes. We analyzed the pathogenic
findings of the two groups.
Results: There were statistically significant differences in age between the two groups
(P = 0.001). Leukocytes (P = 0.012), blood platelets (P = 0.034), fibrinogen (P = 0.037),
D-dimer (P = 0.000), calcitonin ogen (P = 0.015), ultrasensitive C-reactive protein or C-reactive
protein (CRP) (P = 0.000), serum amyloid A (P = 0.000), and erythrocyte sedimentation rate
(P = 0.003) were higher in the case group than in the control group. Albumin was lower in the
case group than in the control group. All differences were statistically significant. The infection
rates of Klebsiella pneumoniae (P = 0.030), Pseudomonas aeruginosa (P = 0.043), and Candida
albicans (P = 0.032) were significantly different between the two groups.
Conclusion: Compared with those without diabetes, the infection rates of Klebsiella pneumoniae,
Pseudomonas aeruginosa, and Candida albicans were higher in patients with combined CAP/T2D.
