Login Register Cart 0
Generic placeholder image

Central Nervous System Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

A Comprehensive Review of the Pharmacological Effects of Genus Ferula on Central Nervous System Disorders

Author(s): Seyyed Majid Bagheri* and Mansour Esmailidehaj

Volume 24, Issue 2, 2024

Published on: 21 November, 2023

Page: [105 - 116] Pages: 12

DOI: 10.2174/0118715249256485231031043722

Price: $65

Open Access Journals Promotions 2
Abstract

Background: Plants of the genus Ferula have long been used to treat neurological diseases such as Alzheimer's disease (AD), pain, depression, and seizures. The main compounds include coumarins, monoterpenes, sulfide compounds, and polyphenol compounds, which can improve the functioning of the nervous system.

Objective: This article has been compiled with the aim of collecting evidence and articles related to the Ferula effects on central nervous system disease.

Methods: This review article was prepared by searching the terms Ferula and analgesic, anticonvulsant, antidepressant, anti-multiple sclerosis, anti-dementia, and neuroprotective effects.The relevant information was collected through searching electronic databases such as ISI Web of Knowledge, PubMed, and Google Scholar.

Results: Genus Ferula has a protective effect on nerve cells by reducing cytokines such as IL-6, IL- 1b, and TNF-α. Therefore, the effects of Ferula plants and their effective ingredients can be used to prevent or improve diseases that destroy the nervous system. The members of this genus play a role in strengthening and improving the antioxidant system, reducing the level of oxidative stress, and inhibiting or reducing inflammatory factors in the nervous system.

Conclusion: Although the effects of several species of Ferula on the nervous system have been investigated, most studies have not clearly identified the molecular mechanisms as well as the specific functional regions of the brain. The present study was compiled in order to investigate different aspects of the effects of Ferula plants on the central nervous system.

Keywords: Ferula, neuroprotective, anticonvulsant, antidepressant, antinociceptive, anti-dementia.

Next »
Graphical Abstract

[1]
Bussmann, R.W.; Glenn, A.; Sharon, D. Healing the body and soul: Traditional remedies for “magical” ailments, nervous system and psychosomatic disorders in Northern Peru. Afr. J. Pharm. Pharmacol., 2010, 4, 580-629.
[2]
Isroilovich, A.E.; Kodirovich, K.N.; Jumanazarovich, M.R. Hereditary diseases of the nervous system, their prevalence and epidemiological status. Cent Asian J Med Nat Sci, 2022, 3, 127-132.
[3]
Zhang, J.; He, Y.; Jiang, X.; Jiang, H.; Shen, J. Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products. Sci. China Life Sci., 2019, 62(10), 1332-1367.
[http://dx.doi.org/10.1007/s11427-019-9587-y] [PMID: 31444682]
[4]
Bagheri, S.; Yadegari, M.; Behpur, M.; Javidmehr, D. Antilithiatic and hepatoprotective effects of Ferula assa-foetida oleo-gum-resin on ethylene glycol-induced lithiasis in rats. Urol. Sci., 2018, 0(0), 0.
[http://dx.doi.org/10.4103/UROS.UROS_10_18]
[5]
Gholami, O.; Shamsara, J. Comparison of the cytotoxic effects of umbelliprenin and auraptene. Int. J. Pharm. Pharm. Sci., 2016, 8, 1-4.
[6]
Iranshahi, M.; Rezaee, R.; Najaf Najafi, M.; Haghbin, A.; Kasaian, J. Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents. Avicenna J. Phytomed., 2018, 8(4), 296-312.
[PMID: 30377589]
[7]
Kapoor, L.D. Hand book of Ayurvedic medicinal plants, 1st ed; CRC Press: Boca Raton, 2005.
[8]
Eigner, D.; Scholz, D. The magic book of the Gyani Dolma. Pharm. Unserer Zeit, 1990, 19(4), 141-152.
[http://dx.doi.org/10.1002/pauz.19900190406] [PMID: 2388925]
[9]
Ross, I.A. Chemical Constituents; Traditional, and Modern Medicinal Uses, 2001.
[10]
Mohammadhosseini, M.; Venditti, A.; Sarker, S.D.; Nahar, L.; Akbarzadeh, A. The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review. Ind. Crops Prod., 2019, 129, 350-394.
[http://dx.doi.org/10.1016/j.indcrop.2018.12.012]
[11]
Nguir, A.; Mabrouk, H.; Douki, W.; Ben Ismail, M.; Ben Jannet, H.; Flamini, G.; Hamza, M.A. Chemical composition and bioactivities of the essential oil from different organs of Ferula communis L. growing in Tunisia. Med. Chem. Res., 2016, 25(3), 515-525.
[http://dx.doi.org/10.1007/s00044-016-1506-1]
[12]
Zargari, A. Medicinal Plants;; Tehran University Press: Tehran, 1970, 4, pp. 42-45.
[13]
Ghasemi, Y.; Faridi, P.; Mehregan, I.; Mohagheghzadeh, A. Ferula gummosa fruits: An aromatic antimicrobial agent. Chem. Nat. Compd., 2005, 41(3), 311-314.
[http://dx.doi.org/10.1007/s10600-005-0138-3]
[14]
Mandegary, A.; Sayyah, M.; Heidari, M.R. Antinociceptive and anti-inflammatory activity of the seed and root extracts of Ferula gummosa Boiss in mice and rats. Daru, 2004, 12, 58-62.
[15]
Sadraei, H.; Asghari, G.R.; Hajhashemi, V.; Kolagar, A.; Ebrahimi, M. Spasmolytic activity of essential oil and various extracts of Boiss. on ileum contractions. Phytomedicine, 2001, 8(5), 370-376.
[http://dx.doi.org/10.1078/0944-7113-00052] [PMID: 11695880]
[16]
Abu-Zaiton, A.S. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak. J. Biol. Sci., 2010, 13(2), 97-100.
[http://dx.doi.org/10.3923/pjbs.2010.97.100] [PMID: 20415145]
[17]
Bagheri, S.M.; Hedesh, S.T.; Mirjalili, A.; Dashti-R, M.H. Evaluation of anti-inflammatory and some possible mechanisms of antinociceptive effect of Ferula assa foetida oleo gum resin. J. Evid. Based Complementary Altern. Med., 2016, 21(4), 271-276.
[http://dx.doi.org/10.1177/2156587215605903] [PMID: 26427790]
[18]
Soudamini, K.K.; Unnikrishnan, M.C.; Sukumaran, K.; Kuttan, R. Mutagenicity and anti-mutagenicity of selected spices. Indian J. Physiol. Pharmacol., 1995, 39(4), 347-353.
[PMID: 8582746]
[19]
Lee, C.L.; Chiang, L.C.; Cheng, L.H.; Liaw, C.C.; Abd El-Razek, M.H.; Chang, F.R.; Wu, Y.C.; Influenza, A. H1N1) antiviral and cytotoxic agents from Ferula assa-foetida. J. Nat. Prod., 2009, 72(9), 1568-1572.
[http://dx.doi.org/10.1021/np900158f] [PMID: 19691312]
[20]
Bagheri, S.M.; Abdian-Asl, A.; Moghadam, M.T.; Yadegari, M.; Mirjalili, A.; Zare-Mohazabieh, F.; Momeni, H. Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice. J. Ayurveda Integr. Med., 2017, 8(3), 152-158.
[http://dx.doi.org/10.1016/j.jaim.2017.02.013] [PMID: 28690055]
[21]
Bagheri, S.M.; Hejazian, S.H.; Bafghi, A.F. Antileishmanial activity of Ferula assa-foetida oleo gum resin against Leishmania major: An in vitro study. J. Ayurveda Integr. Med., 2014, 5(4), 223-226.
[http://dx.doi.org/10.4103/0975-9476.146567] [PMID: 25624696]
[22]
Hejazian, S.H.; Dashti-R, M.H.; Bagheri, S.M. The relaxant effect of seed fs essential oil and oleo-gum-resin of Ferula assa-foetida on isolated rat’s ileum. Ann. Med. Health Sci. Res., 2014, 4(2), 238-241.
[http://dx.doi.org/10.4103/2141-9248.129050] [PMID: 24761245]
[23]
Zhang, S.H.; Liu, D.; Hu, Q.; Zhu, J.; Wang, S.; Zhou, S. Ferulic acid ameliorates pentylenetetrazol-induced seizures by reducing neuron cell death. Epilepsy Res., 2019, 156, 106183.
[http://dx.doi.org/10.1016/j.eplepsyres.2019.106183] [PMID: 31404716]
[24]
Asghari, J.; Atabaki, V.; Baher, E.; Mazaheritehrani, M. Identification of sesquiterpene coumarins of oleo-gum resin of Ferula assa-foetida L. from the Yasuj region. Nat. Prod. Res., 2016, 30(3), 350-353.
[http://dx.doi.org/10.1080/14786419.2015.1050669] [PMID: 26134757]
[25]
Nazari, Z.E.; Iranshahi, M. Biologically active sesquiterpene coumarins from Ferula species. Phytother. Res., 2011, 25(3), 315-323.
[http://dx.doi.org/10.1002/ptr.3311] [PMID: 21031633]
[26]
Kwon, C.S.; Wagner, R.G.; Carpio, A.; Jetté, N.; Newton, C.R.; Thurman, D.J. The worldwide epilepsy treatment gap: A systematic review and recommendations for revised definitions – A report from the ILAE Epidemiology Commission. Epilepsia, 2022, 63(3), 551-564.
[http://dx.doi.org/10.1111/epi.17112] [PMID: 35001365]
[27]
Lِscher, W.; Potschka, H.; Sisodiya, S.M.; Vezzani, A. Drug resistance in epilepsy: Clinical impact, potential mechanisms, and new innovative treatment options. Pharmacol. Rev., 2020, 72(3), 606-638.
[http://dx.doi.org/10.1124/pr.120.019539] [PMID: 32540959]
[28]
Łukawski, K.; Czuczwar, S.J. Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it. Expert Opin. Drug Metab. Toxicol., 2021, 17(9), 1075-1090.
[http://dx.doi.org/10.1080/17425255.2021.1959912] [PMID: 34310255]
[29]
Akyüz, E. Köklü, B.; Ozenen, C.; Arulsamy, A.; Shaikh, M.F. Elucidating the potential side effects of current anti-seizure drugs for epilepsy. Curr. Neuropharmacol., 2021, 19(11), 1865-1883.
[http://dx.doi.org/10.2174/1570159X19666210826125341] [PMID: 34525933]
[30]
Bagheri, S.M.; Sahebkar, A.; Gohari, A.R.; Saeidnia, S.; Malmir, M.; Iranshahi, M. Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species. Pharm. Biol., 2010, 48(3), 242-246.
[http://dx.doi.org/10.3109/13880200903081796] [PMID: 20645807]
[31]
Sayyah, M.; Mandgary, A.; Kamalinejad, M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J. Ethnopharmacol., 2002, 82(2-3), 105-109.
[http://dx.doi.org/10.1016/S0378-8741(02)00166-6] [PMID: 12241984]
[32]
Rezvani, M.E.; Vahidi, A.R.; Esmaili, M.; Bagheri, S.M. Anticonvulsant effect of ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. N. Am. J. Med. Sci., 2014, 6(8), 408-412.
[http://dx.doi.org/10.4103/1947-2714.139296] [PMID: 25210675]
[33]
Kiasalari, Z.; Khalili, M.; Roghani, M.; Heidari, H.; Azizi, Y. Antiepileptic and antioxidant effect of hydroalcoholic extract of ferula assa foetida gum on pentylentetrazole-induced kindling in male mice. Basic Clin. Neurosci., 2013, 4(4), 299-306.
[PMID: 25337361]
[34]
Sotudeh, F.S.; Fereidoni, M.; Moghimi, A. The effects of stem and leaves hydroalcoholic extract of Ferula szowitziana on PTZ induced seizure in male rats. 3rd Neuroscience Congress, 2014, 10-29.
[35]
Achliya, G.S.; Wadodkar, S.G.; Dorle, A.K. Evaluation of sedative and anticonvulsant activities of Unmadnashak Ghrita. J. Ethnopharmacol., 2004, 94(1), 77-83.
[http://dx.doi.org/10.1016/j.jep.2004.04.020] [PMID: 15261966]
[36]
Anwar, N.; Khan, M.A.; Bukhari, M.; Ahmed, H.; Zaidi, A.A.; Arshad, H. Anti-epileptic potential of ziziphus vulgaris and ferula asafoetida extracts in drug induced seizure models of experimental mice. RADS-JPPS, 2020, 8(1), 37-46.
[http://dx.doi.org/10.37962/jpps.v8i1.344]
[37]
Sayah, M; Mandegari, A. Anticonvulsant effect of Ferula gummosa root extract against experimental seizures. Archive of SID, 2003.
[38]
Bashiri-Nahnjeh, M.; Sarihi, A.; Ebadi, A.; Dastan, D.; Mohammadi, M. In silico molecular modeling, neuro-behavioral profile, and toxicity assessment of the essential oil of Ferula gummosa Boiss. as an anti-seizure agent. J. Ethnopharmacol., 2023, 309, 116347.
[http://dx.doi.org/10.1016/j.jep.2023.116347] [PMID: 36894108]
[39]
Felipe, C.F.B.; Albuquerque, A.M.S.; de Pontes, J.L.X.; de Melo, J. Í.V.; Rodrigues, T.C.M.L.; de Sousa, A.M.P.; Monteiro, Á,B.; Ribeiro, A.E.S.; Lopes, J.P.; de Menezes, I.R.A.; de Almeida, R.N. Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice. Fundam. Clin. Pharmacol., 2019, 33(2), 181-190.
[http://dx.doi.org/10.1111/fcp.12416] [PMID: 30230028]
[40]
Tayeboon, G.S.; Tavakoli, F.; Hassani, S.; Khanavi, M.; Sabzevari, O.; Ostad, S.N. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity. In Vitro Cell. Dev. Biol. Anim., 2013, 49(9), 706-715.
[http://dx.doi.org/10.1007/s11626-013-9656-7] [PMID: 23949776]
[41]
Jang, Y.; Kim, M.; Hwang, S.W. Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J. Neuroinflammation, 2020, 17(1), 30.
[http://dx.doi.org/10.1186/s12974-020-1703-1] [PMID: 31969159]
[42]
Świeboda, P.; Filip, R.; Prystupa, A.; Drozd, M. Assessment of pain: Types, mechanism and treatment. Pain, 2013, 1(Spec no), 2-7.
[PMID: 25000833]
[43]
Viswanath, O.; Urits, I.; Burns, J.; Charipova, K.; Gress, K.; McNally, A.; Urman, R.D.; Welschmeyer, A.; Berger, A.A.; Kassem, H.; Sanchez, M.G.; Kaye, A.D.; Eubanks, T.N.; Cornett, E.M.; Ngo, A.L. Central neuropathic mechanisms in pain signaling pathways: Current evidence and recommendations. Adv. Ther., 2020, 37(5), 1946-1959.
[http://dx.doi.org/10.1007/s12325-020-01334-w] [PMID: 32291648]
[44]
Shaban, K.A.; Alzubaidy, M.H.; Faris, G.A. Evaluation of the antinociceptive effect of xylazine and it’s interaction with metoclopramide in the acute pain model in mice. Iraqi J. Vet. Sci., 2020, 34(2), 383-388.
[http://dx.doi.org/10.33899/ijvs.2019.126070.1226]
[45]
Bagheri, S.; Mohamadsadeghi, H.; Hejazian, E. Antinociceptive effect of seed’s essential oil of Ferula assa-foetida in Mice. Int. J. Clin. Exp. Physiol., 2017, 4(1), 34-37.
[http://dx.doi.org/10.4103/ijcep.ijcep_5_17]
[46]
Radulović N.S.; Zlatković D.B.; Randjelović P.J.; Stojanović N.M.; Novaković S.B.; Akhlaghi, H. Chemistry of spices: Bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice. Food Funct., 2013, 4(12), 1751-1758.
[http://dx.doi.org/10.1039/c3fo60319a] [PMID: 24113913]
[47]
Bagheri, S.M.; Dashti-R, M.H.; Morshedi, A. Antinociceptive effect of Ferula assa-foetida oleo-gum-resin in mice. Res. Pharm. Sci., 2014, 9(3), 207-212.
[PMID: 25657791]
[48]
Kamran, S.K.S.; Rasul, A.; Anwar, H.; Irfan, S.; Ullah, K.S.; Malik, S.A.; Razzaq, A.; Aziz, N.; Braidy, N.; Hussain, G. Ferula asafoetida Linn. is effective for early functional recovery following mechanically induced insult to the sciatic nerve of a mouse model. Trop. J. Pharm. Res., 2020, 19(9), 1903-1910.
[http://dx.doi.org/10.4314/tjpr.v19i9.15]
[49]
Zarifkar, A.A. Evaluation of antinociceptive effect of galbanum by formalin test in mice. Armaghane Danesh, 2007, 12(1), 19-27.
[50]
Emami Razavi, Z.; Karimi, M.; Khamessi, M. Effects of galbanum oil on patients with knee osteoarthritis: A randomized controlled clinical trial. Ann. Phys. Rehabil. Med., 2018, 61, e535.
[http://dx.doi.org/10.1016/j.rehab.2018.05.1245]
[51]
Keramati, K. Asghari BaghKheirati, A. The effect of hydroalcoholic extract of Ferula gummosa on visceral pain in mice: Experimental study. Anesthesiol Pain, 2016, 7, 30-37.
[52]
Nasri, S.; Ghorbani Nohooji, M.; Amin, G.R.; Sharifi, A.S.; Borbor, M.; Shamohammadi, F.; Moghaddasi, M. Phytochemical study of methanolic extract of ferula persica willd. inflorescence and its antinociceptive effect in male mice. Faslnamah-i Giyahan-i Daruyi, 2018, 17, 136-144.
[53]
Geroushi, A.; Auzi, A.A.; Elhwuegi, A.S.; Elzawam, F.; El-Sherif, A.; Nahar, L.; Sarker, S.D. Antinociceptive and anti-inflammatory activity of Ferula hermonis root oil in experimental animals. Lat. Am. J. Pharm., 2010, 29.
[54]
Saghravanian, S.; Fereidoni, M.; Asadollahi, A. The effect of Ferula szowitsiana extract on chemical pain in male Wistar rats. Arch. Biol. Sci., 2018, 70(2), 365-369.
[http://dx.doi.org/10.2298/ABS170326054S]
[55]
Huang, Y.; Hu, W.; Li, L.; Liu, Y. Effect of Ferula sinkiangensis KM Shen on pain threshold and Fos protein expression and astrocyte activation in the spinal cord of neuropathic pain rats. Chinese J Tissue Eng Res, 2015, 19, 6485.
[56]
Ramezani, M.; Hosseinzadeh, H.; Mojtahedi, K. Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. J. Ethnopharmacol., 2001, 77(1), 71-75.
[http://dx.doi.org/10.1016/S0378-8741(01)00263-X] [PMID: 11483380]
[57]
Bao, X.H.; Li, Y.P.; Li, Q.; Cheng, Y.X.; Jiao, Y.B.; Zhang, H.X.; Yan, Y.M. Racemic norneolignans from the resin of Ferula sinkiangensis and their COX-2 inhibitory activity. Fitoterapia, 2023, 164, 105341.
[http://dx.doi.org/10.1016/j.fitote.2022.105341] [PMID: 36309142]
[58]
Iranshahi, M.; Askari, M.; Sahebkar, A.; Hadjipavlou, L.D. Evaluation of antioxidant, anti-inflammatory and lipoxygenase inhibitory activities of the prenylated coumarin umbelliprenin. DARU J. Pharm. Sci., 2009, 17(2), 99-103.
[59]
Wu, Y.; Zhang, C.; Liu, H.; Duan, C.; Li, C.; Fan, J.; Li, H.; Chen, L.; Xu, H.; Li, X.; Guo, Y.; Wang, Y.; Li, X.; Li, J.; Zhang, T.; You, Y.; Li, H.; Yang, S.; Tao, X.; Xu, Y.; Lao, H.; Wen, M.; Zhou, Y.; Wang, J.; Chen, Y.; Meng, D.; Zhai, J.; Ye, Y.; Zhong, Q.; Yang, X.; Zhang, D.; Zhang, J.; Wu, X.; Chen, W.; Dennis, C.L.; Huang, H. Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China. Am. J. Obstet. Gynecol., 2020, 223(2), 240.e1-240.e9.
[http://dx.doi.org/10.1016/j.ajog.2020.05.009] [PMID: 32437665]
[60]
Wang, Y.S.; Shen, C.Y.; Jiang, J.G. Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery. Pharmacol. Res., 2019, 150, 104520.
[http://dx.doi.org/10.1016/j.phrs.2019.104520] [PMID: 31706012]
[61]
Peng, S; Zhou, Y; Lu, M; Wang, Q Review of herbal medicines for the treatment of depression. Nat. Prod. Commun., 2022, 17, 1934578X221139082.
[http://dx.doi.org/10.1177/1934578X221139082]
[62]
Kumar, T.B.; Reddy, D.V.J.; Rushendran, R.; Mamatha, T.; Roja, J.; Roopavani, T. Antidepressant activity of ethanolic extract of oleo gum resins of Ferula asafoetida Linn. J. Pre-Clin. Clin. Res., 2017, 11(1), 50-60.
[http://dx.doi.org/10.26444/jpccr/75721]
[63]
Alqasoumi, S. Anxiolytic effect of Ferula assafoetida L. in rodents. J. Pharmacogn. Phytother., 2012, 4(6), 86-90.
[http://dx.doi.org/10.5897/JPP12.027]
[64]
Batra, S.; Kumar, A.; Sharma, A. Isolation, characterization and antianxiety activity of pentacosan-13-ol from ferula sumbul hook. roots. JBAPN, 2018, 8(3), 171-179.
[http://dx.doi.org/10.1080/22311866.2018.1472037]
[65]
Batra, S.; Kumar, A.; Sharma, A. GABA and 5-HT receptor mediated anxiolytic effect of essential oil of Ferula sumbul Hook. roots. Nat. Prod. J., 2020, 10(3), 262-271.
[http://dx.doi.org/10.2174/2210315509666190211123646]
[66]
Kim, J.K.; Park, S.U. A recent overview on the biological and pharmacological activities of ferulic acid. EXCLI J., 2019, 18, 132-138.
[PMID: 30956646]
[67]
Zeni, A.L.B.; Zomkowski, A.D.E.; Maraschin, M.; Rodrigues, A.L.S.; Tasca, C.I. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: Evidence for the involvement of the serotonergic system. Eur. J. Pharmacol., 2012, 679(1-3), 68-74.
[http://dx.doi.org/10.1016/j.ejphar.2011.12.041] [PMID: 22266492]
[68]
Chen, J.; Lin, D.; Zhang, C.; Li, G.; Zhang, N.; Ruan, L.; Yan, Q.; Li, J.; Yu, X.; Xie, X.; Pang, C.; Cao, L.; Pan, J.; Xu, Y. Antidepressant-like effects of ferulic acid: Involvement of serotonergic and norepinergic systems. Metab. Brain Dis., 2015, 30(1), 129-136.
[http://dx.doi.org/10.1007/s11011-014-9635-z] [PMID: 25483788]
[69]
Lenzi, J.; Rodrigues, A.F. Rós, A.S.; de Castro, B.B.; de Lima, D.D.; Magro, D.D.D.; Zeni, A.L.B. Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system. Metab. Brain Dis., 2015, 30(6), 1453-1463.
[http://dx.doi.org/10.1007/s11011-015-9725-6] [PMID: 26340979]
[70]
Hugo, J.; Ganguli, M. Dementia and cognitive impairment: Epidemiology, diagnosis, and treatment. Clin. Geriatr. Med., 2014, 30(3), 421-442.
[http://dx.doi.org/10.1016/j.cger.2014.04.001] [PMID: 25037289]
[71]
Zekry, D.; Hauw, J.J.; Gold, G. Mixed dementia: Epidemiology, diagnosis, and treatment. J. Am. Geriatr. Soc., 2002, 50(8), 1431-1438.
[http://dx.doi.org/10.1046/j.1532-5415.2002.50367.x] [PMID: 12165002]
[72]
Kwon, C.Y.; Lee, B. Herbal medicine for behavioral and psychological symptoms of dementia: A systematic review and meta-analysis. Front. Pharmacol., 2021, 12, 713287.
[http://dx.doi.org/10.3389/fphar.2021.713287] [PMID: 34385925]
[73]
Adiga, S.; Bhat, P.; Chaturvedi, A.; Bairy, K.L.; Kamath, S. Vijayalakshmi, Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J. Pharmacol., 2012, 44(1), 82-87.
[http://dx.doi.org/10.4103/0253-7613.91873] [PMID: 22345876]
[74]
Bagheri, S.M.; Dashti-R, M.H. Influence of asafoetida on prevention and treatment of memory impairment induced by d-galactose and NaNO2 in mice. Am. J. Alzheimers Dis. Other Demen., 2015, 30(6), 607-612.
[http://dx.doi.org/10.1177/1533317515576388] [PMID: 25788433]
[75]
Narayanan, R.; Gilbert, B.; Ravichandran, S.; Bhuvaneswari, K. Psychopharmacological characterization of effects of Ferula asafoetida linn. formulation in mouse on a Y-maze, EPM, and open field apparatus. Int. J. Basic Clin. Pharmacol., 2017, 6(9), 2254-2258.
[http://dx.doi.org/10.18203/2319-2003.ijbcp20173755]
[76]
Nazir, N.; Nisar, M.; Zahoor, M.; Uddin, F.; Ullah, S.; Ullah, R.; Ansari, S.A.; Mahmood, H.M.; Bari, A.; Alobaid, A. Phytochemical analysis, in vitro anticholinesterase, antioxidant activity and in vivo nootropic effect of ferula ammoniacum (dorema ammoniacum) d. don. in scopolamine-induced memory impairment in mice. Brain Sci., 2021, 11(2), 259.
[http://dx.doi.org/10.3390/brainsci11020259] [PMID: 33669503]
[77]
Knight, R.; Khondoker, M.; Magill, N.; Stewart, R.; Landau, S. A systematic review and meta-analysis of the effectiveness of acetylcholinesterase inhibitors and memantine in treating the cognitive symptoms of dementia. Dement. Geriatr. Cogn. Disord., 2018, 45(3-4), 131-151.
[http://dx.doi.org/10.1159/000486546] [PMID: 29734182]
[78]
Bagheri, S.M.; Allahtavakoli, M.; Moradi, A. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease. J. Complement. Integr. Med., 2023.
[http://dx.doi.org/10.1515/jcim-2022-0284] [PMID: 36857494]
[79]
Dobson, R.; Giovannoni, G. Multiple sclerosis – a review. Eur. J. Neurol., 2019, 26(1), 27-40.
[http://dx.doi.org/10.1111/ene.13819] [PMID: 30300457]
[80]
Grubić, Kezele, T.; Ćurko-Cofek, B. Neuroprotective panel of olive polyphenols: Mechanisms of action, anti-demyelination, and anti-stroke properties. Nutrients, 2022, 14(21), 4533.
[http://dx.doi.org/10.3390/nu14214533] [PMID: 36364796]
[81]
Bagheri, S.M.; Maghsoudi, M.J.; Yadegari, M. Preventive effect of Ferula asafoetida oleo gum resin on histopathology in cuprizone-induced demyelination mice. Int. J. Prev. Med., 2020, 11, 179.
[PMID: 33456735]
[82]
Abdi, S.; Hatami Nemati, H.; Khakpay, R.; Dehghan, G. Investigating the Effects of Ferula Szowitsiana (Ferula szowitsiana L.) on Antioxidant System Parameters in the Hippocampus of Male Rats to Follow Inducemultiple Sclerosis Disease. JIUMS, 2017, 25(1), 33-44.
[http://dx.doi.org/10.29252/sjimu.25.1.33]
[83]
Sabzehzari, M.; Naghavi, M.R.; Bozari, M.; Orafai, H.M.; Johnston, T.P.; Sahebkar, A. Pharmacological and therapeutic aspects of plants from the genus Ferula: a comprehensive review. Mini Rev. Med. Chem., 2020, 20(13), 1233-1257.
[http://dx.doi.org/10.2174/1389557520666200505125618] [PMID: 32368975]
[84]
Saxena, S.; Caroni, P. Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration. Neuron, 2011, 71(1), 35-48.
[http://dx.doi.org/10.1016/j.neuron.2011.06.031] [PMID: 21745636]
[85]
Fu, W.; Zhuang, W.; Zhou, S.; Wang, X. Plant-derived neuroprotective agents in Parkinson’s disease. Am. J. Transl. Res., 2015, 7(7), 1189-1202.
[PMID: 26328004]
[86]
Topdas, E.F.; Sengul, M.; Taghizadehghalehjoughi, A.; Hacimuftuoglu, A. Neuroprotective potential and antioxidant activity of various solvent extracts and essential Oil of Ferula orientalis L. J. Essent. Oil-Bear. Plants, 2020, 23(1), 121-138.
[http://dx.doi.org/10.1080/0972060X.2020.1729247]
[87]
Homayouni Moghadam, F.; Vakili Zarch, B.; Shafiei, M. Double edged effect of gum-resin of ferula assa-foetida on lifespan of neurons. Iran. J. Basic Med. Sci., 2013, 16(4), 668-671.
[PMID: 24250950]
[88]
Homayouni Moghadam, F.; Dehghan, M.; Zarepur, E.; Dehlavi, R.; Ghaseminia, F.; Ehsani, S.; Mohammadzadeh, G.; Barzegar, K. Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice. J. Ethnopharmacol., 2014, 154(1), 183-189.
[http://dx.doi.org/10.1016/j.jep.2014.03.069] [PMID: 24709312]
[89]
Raafat, K. Phytochemical and neuroprotective investigation on ferula hermonis. BAU Journal-Health Wellbeing, 2019, 1, 3.
[90]
Sadeghnia, H.R.; Rajabian, A.; Ghorbani, A.; Moradzadeh, M.; Hosseini, A. Effects of standardized extract of Ferula gummosa root on glutamate-induced neurotoxicity. Folia Neuropathol., 2017, 55(4), 340-346.
[http://dx.doi.org/10.5114/fn.2017.72399] [PMID: 29363909]
[91]
Mi, Y.; Jiao, K.; Xu, J.; Wei, K.; Liu, J.; Meng, Q.; Guo, T.; Zhang, X.; Zhou, D.; Qing, D.; Sun, Y.; Li, N.; Hou, Y. Kellerin from Ferula sinkiangensis exerts neuroprotective effects after focal cerebral ischemia in rats by inhibiting microglia-mediated inflammatory responses. J. Ethnopharmacol., 2021, 269, 113718.
[http://dx.doi.org/10.1016/j.jep.2020.113718] [PMID: 33352239]

Rights & Permissions Print Cite
Article Metrics
28
2
Wayfinder Image
Open Access Journals Promotions
World Prematurity Day
© 2024 Bentham Science Publishers | Privacy Policy