Title:Tertiary Hyperparathyroidism and Extra Skeletal Calcification in End Stage
Kidney Disease Patients: Case-series and Literature Review
Volume: 5
Author(s): Sanaa Majdi Alahbabi, Meera Ahmed Alshehhi, Rawdha Almeqdad Alkaabi, Fakhriya Alalawi*Amna Alhadari
Affiliation:
- Department of Nephrology, Dubai Academic Health Corporation (DAHC), Dubai, United Arab Emirates
Keywords:
Tertiary hyperparathyroidism (THPT), Parathyroid Hormone (PTH), End-Stage Kidney Disease (ESKD), Brown tumour, Calciphylaxis, Dialysis.
Abstract:
Background:
Tertiary hyperparathyroidism (THPT) is a well-known complication of end-stage kidney disease (ESKD), resulting from a loss of functional renal
tissue with subsequent alterations in calcium and phosphate metabolism. Tertiary hyperparathyroidism reflects severe parathyroid hyperplasia with
autonomous excessive secretion of parathyroid hormone (PTH) that is no longer responsive to the concentration of plasma calcium and leads to
abnormal bone remodelling, soft tissue calcifications, vasculopathy, and other systemic complications.
Case Presentation:
The authors, hereby, highlight varied presentations of tertiary hyperparathyroidism (THPT) by presenting 3 interesting cases, describing their
clinical course and outcomes. Through sharing these experiences and insights, we hope to contribute to a better understanding of THPT and its
optimal management in patients with ESKD.
Conclusion:
THPT can have a significant impact on patient health and quality of life. Despite the widespread use of interventions, such as vitamin D analogues,
calcimimetics and parathyroidectomy, THPT remains a significant clinical challenge for patients with ESKD.
