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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Perspective

The Thyroid-cardiac Axis: Thyroid Function, Cardiac Rhythmology, and Sudden Cardiac Death

Author(s): Michael Spartalis*, Eleftherios Spartalis, Stavroula A. Paschou, Dimitrios C. Iliopoulos and Gerasimos Siasos

Volume 24, Issue 10, 2024

Published on: 03 November, 2023

Page: [1127 - 1130] Pages: 4

DOI: 10.2174/0118715303243951231024112208

Abstract

It is well known that thyroid dysfunction increases the risk of cardiovascular mortality and morbidity. The pleiotropic effect of thyroid hormones has a profound effect on the cardiovascular system, influencing both the formation of a normal cardiac rhythm and rhythm disturbance. A number of research studies have demonstrated correlations between TSH and FT4 levels and significant cardiovascular events. The pathophysiological mechanisms underlying these complex associations are, however, inadequately defined. A system-based examination of the relationship between thyroid homeostasis and cardiovascular disease could pave the way for novel study areas and a more individualised strategy for the management of individuals at cardiovascular risk.

Keywords: Thyroid, arrhythmia, sudden cardiac death, hyperthyroidism, hypothyroidism, cardiovascular.

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