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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Mini-Review Article

Mitochondrial Inherited Disorders and their Correlation with Neurodegenerative Diseases

Author(s): Sofjana Gushi and Vasileios Balis*

Volume 24, Issue 4, 2024

Published on: 01 November, 2023

Page: [381 - 393] Pages: 13

DOI: 10.2174/0118715303250271231018103202

Price: $65

Abstract

Mitochondria are essential organelles for the survival of a cell because they produce energy. The cells that need more mitochondria are neurons because they perform a variety of tasks that are necessary to support brain homeostasis. The build-up of abnormal proteins in neurons, as well as their interactions with mitochondrial proteins, or MAM proteins, cause serious health issues. As a result, mitochondrial functions, such as mitophagy, are impaired, resulting in the disorders described in this review. They are also due to mtDNA mutations, which alter the heritability of diseases. The topic of disease prevention, as well as the diagnosis, requires further explanation and exploration. Finally, there are treatments that are quite promising, but more detailed research is needed.

Keywords: Mitochondria, neurodegeneration, mitochondrial DNA, mitophagy, heritability, homeostasis.

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