Review Article

SGLT-2抑制剂:2型糖尿病的新一代治疗方法

卷 31, 期 30, 2024

发表于: 19 October, 2023

页: [4781 - 4806] 页: 26

弟呕挨: 10.2174/0109298673251493231011192520

价格: $65

摘要

近年来,2型糖尿病(T2DM)已成为全球关注的问题,主要发生在高度发达的西方社会。T2DM可引起全身并发症,如动脉粥样硬化性心脏病、缺血性中风、外周动脉疾病、肾衰竭、糖尿病相关黄斑病变和视网膜病变。不断增长的T2DM患者数量和长期T2DM相关并发症的治疗给公共卫生系统带来了压力和压力。因此,防治2型糖尿病和开发新药的战略是至关重要的全球公共卫生要求。预防措施仍然是预防2型糖尿病最有效的方法,除此之外,新的和高效的治疗方法正在出现。在下一代T2DM治疗的聚光灯下,钠-葡萄糖共转运蛋白2 (SGLT-2)抑制剂被认为是最有效的透视治疗方法。SGLT-2抑制剂(SGLT2i)包括苯连菌素衍生物,如卡格列净、达格列净、恩格列净和埃图格列净。SGLT-2和SGLT-1是SGLT蛋白家族的成员,通过Na+/K+ atp酶介导的主动转运在葡萄糖吸收中发挥作用。SGLT-2仅存在于肾脏,特别是近端小管中,负责90%以上的葡萄糖吸收。抑制SGLT-2减少葡萄糖吸收,从而增加尿糖排泄,降低血糖水平。因此,抑制SGLT-2活性最终可缓解t2dm相关症状,预防或延缓t2dm相关的全身慢性并发症。本综述旨在更详细地了解SGLT2i对血糖调节的作用,这是控制t2dm相关心血管并发症的先决条件。

关键词: 2型糖尿病,T2DM,钠-葡萄糖转运蛋白,SGLT-2抑制剂,心血管并发症,糖尿病。

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