Title:TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis
Volume: 24
Issue: 11
Author(s): Lu Miao*, Li Jing, Buze Chen, Tian Zeng and Youguo Chen*
Affiliation:
- Department of Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215026, China
- Department of Gynecology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221009, China
- Department of Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215026, China
Keywords:
Pan cáncer, TPD52, prognosis, immune infiltration, drug sensitivity, genomic alteration.
Abstract:
Background: Some tumors have a poor prognosis regarding TPD52 (tumor
protein D52). This study aims to explore TPD52's role in the cancer process from a
pan-cancer perspective.
Methods: A pan-cancer analysis was conducted to investigate how TPD52 may be
involved in cancer as well as its association with prognosis.
Results: A variety of human cancers express TPD52 abnormally and correlate with
clinical stage. There was a significant association between low expression of TPD52
and poor survival in BRCA, KIRP, LAML, LIHC, UCEC, and UVM. TPD52 alterations
were most frequently amplified in pan-cancer. The co-occurrence of 10 genes
alterations was found in the TPD52 altered group. There was a significant association
between TPD52 expression and MSI in four cancer types and TMB in twelve cancer
types. There was a significant correlation between TPD52 expression and immunerelated
cell infiltration. A significant correlation was found between TPD52 expression
in many tumor types and 8 immune checkpoint genes. There were signaling pathways
involved in pan-cancer caused by TPD52, including endocytosis, Fc gamma Rmediated
phagocytosis, and so on. TPD52 may be involved in chemotherapy and
chemoresistance.
Conclusion: The TPD52 gene may be important for human cancer treatment.
