Title:Microwave-assisted Synthesis of Heterocycles and their Anti-cancer Activities
Volume: 10
Issue: 2
Author(s): Sasadhar Majhi*Pankaj Kumar Mondal
Affiliation:
- Department of Chemistry (UG & PG), Triveni Devi Bhalotia College, Raniganj, Kazi Nazrul University, West Bengal-
713347, India
Keywords:
Microwave irradiation, bioactive heterocycles, anti-cancer activities, sustainable chemistry, organic synthesis, anticancer, market-selling drugs.
Abstract: One of the most efficient non-conventional heating methods is microwave irradiation. In
organic synthesis, microwave irradiation has become a popular heating technique as it enhances
product yields and purities, reduces reaction time from hours to minutes, and decreases unwanted
side reactions. Microwave-assisted organic synthesis utilizes dielectric volumetric heating as an
alternative activation method, which results in rapid and more selective transformations because of
the uniform heat distribution. Heterocyclic compounds have a profound role in the drug discovery
and development process along with their applications as agrochemicals, fungicides, herbicides,
etc., making them the most prevalent form of biologically relevant molecules. Hence, enormous
efforts have been made to flourish green routes for their high-yielding synthesis under microwave
irradiation as a sustainable tool. Among the different clinical applications, heterocyclic compounds
have received considerable attention as anti-cancer agents. Heterocyclic moieties have always been
core parts of the development of anti-cancer drugs, including market-selling drugs, i.e., 5-fluorouracil,
doxorubicin, methotrexate, daunorubicin, etc., and natural alkaloids, such as vinblastine and
vincristine. In this review, we focus on the developments in the microwave-assisted synthesis of
heterocycles and the anti-cancer activities of particular heterocycles.
