Title:Modulation of the Immune System Mechanisms using Probiotic Bacteria
in Allergic Diseases: Focus on Allergic Retinitis and Food Allergies
Volume: 18
Issue: 1
Author(s): Haleh Forouhandeh, Saiedeh Razi Soofiyani, Kamran Hosseini, Sohrab Minaei Beirami, Hossein Ahangari, Yusif Moammer, Sara Ebrahimzadeh, Masoomeh Kashef Nejad, Afsaneh Farjami*, Fariba Khodaiefar*Vahideh Tarhriz*
Affiliation:
- Food and Drug
Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
- Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
- Department of Traditional Medicine, Faculty of Traditional
Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
- Cardiovascular Center of Excellence,
Louisiana State University Health Sciences Center, New Orleans, LA, USA
Keywords:
Immune system, probiotics, atopic dermatitis, allergic retinitis, epithelial cells, dendritic cells.
Abstract: Allergic illnesses occur when an organism's immune system is excessively responsive
to certain antigens, such as those that are presented in the environment. Some people suffer from a
wide range of immune system-related illnesses including allergic rhinitis, asthma, food allergies,
hay fever, and even anaphylaxis. Immunotherapy and medications are frequently used to treat allergic
disorders. The use of probiotics in bacteriotherapy has lately gained interest. Probiotics are
essential to human health by modulating the gut microbiota in some ways. Due to probiotics' immunomodulatory
properties present in the gut microbiota of all animals, including humans, these
bacterial strains can prevent a wide variety of allergic disorders. Probiotic treatment helps allergy
patients by decreasing inflammatory cytokines and enhancing intestinal permeability, which is
important in the battle against allergy. By altering the balance of Th1 and Th2 immune responses
in the intestinal mucosa, probiotics can heal allergic disorders. Numerous studies have shown a
correlation between probiotics and a reduced risk of allergy disorders. A wide range of allergic
disorders, including atopic dermatitis, asthma, allergic retinitis and food allergies has been proven
to benefit from probiotic bacteria. Therefore, the use of probiotics in the treatment of allergic diseases
offers a promising perspective. Considering that probiotic intervention in the treatment of
diseases is a relatively new field of study, more studies in this regard seem necessary.
