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Review Article

The Function and Modification of Human Defensin 5

Author(s): Xin-Yue Chang, Meng-Wei Zhang, Lin-Jie Zhang* and Lian-Qin Chai*

Volume 30, Issue 10, 2023

Published on: 09 October, 2023

Page: [830 - 840] Pages: 11

DOI: 10.2174/0109298665252235230919071229

Price: $65

Abstract

The antibacterial and antiviral functions of human defensin 5 lay the foundation for its role as a core host protective component. In addition, HD5 also has the function of inhibiting tumor proliferation and immune regulation. However, everything has two sides; cytotoxic and proinflammatory properties may exist, while HD5 performs physiological functions. Accordingly, the modification and engineering of HD5 are particularly important. Therefore, this review summarizes the role of HD5 in various aspects of host defense, as well as modification of HD5 to ameliorate the biological activity, with a view to promoting the clinical use of HD5.

Keywords: HD5, bacterial infection, tumor generation, viral infection, immunity, modification.

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