Title:Role of Flavonoids in Modulation of Mitochondria Dynamics during
Oxidative Stress
Volume: 24
Issue: 9
Author(s): Sachindra Kumar, Vishal Chhabra, Smita Shenoy, Rajni Daksh, Velayutham Ravichandiran, Ravindra Shantakumar Swamy and Nitesh Kumar*
Affiliation:
- Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research (NIPER), Hajipur, Industrial Area Hajipur, Vaishali, 844102, India
Keywords:
Apoptosis, mitochondrial biogenesis, ROS, autophagy, mitochondrial ion channels, mitochondrial fission and fusion.
Abstract:
Background: Flavonoids are a widespread category of naturally occurring polyphenols
distinguished by the flavan nucleus in plant-based foods and beverages, known for their various
health benefits. Studies have suggested that consuming 150-500 mg of flavonoids daily is beneficial
for health. Recent studies suggest that flavonoids are involved in maintaining mitochondrial activity
and preventing impairment of mitochondrial dynamics by oxidative stress.
Objective: This review emphasized the significance of studying the impact of flavonoids on
mitochondrial dynamics, oxidative stress, and inflammatory response.
Methods: This review analysed and summarised the findings related to the impact of flavonoids on
mitochondria from publicly available search engines namely Pubmed, Scopus, and Web of Science.
Description: Any disruption in mitochondrial dynamics can contribute to cellular dysfunction and
diseases, including cancer, cardiac conditions, and neurodegeneration. Flavonoids have been shown
to modulate mitochondrial dynamics by regulating protein expression involved in fission and fusion
events. Furthermore, flavonoids exhibit potent antioxidant properties by lowering the production of
ROS and boosting the performance of antioxidant enzymes. Persistent inflammation is a
characteristic of many different disorders. This is because flavonoids also alter the inflammatory
response by controlling the expression of numerous cytokines and chemokines involved in the
inflammatory process. Flavonoids exhibit an impressive array of significant health effects, making
them an effective therapeutic agent for managing various disorders. Further this review summarised
available mechanisms underlying flavonoids' actions on mitochondrial dynamics and oxidative
stress to recognize the optimal dose and duration of flavonoid intake for therapeutic purposes.
Conclusion: This review may provide a solid foundation for developing targeted therapeutic
interventions utilizing flavonoids, ultimately benefiting individuals afflicted with various disorders.
