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ISSN (Online): 2210-3163

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Review Article

Osthole: A Medicinally Privileged Natural Compound with its Therapeutic Potential

Author(s): Kamran Ansari, Ujjwal Gupta, Antra Sinha, Ankit Sharma and Kalpana Rahate*

Volume 14, Issue 4, 2024

Published on: 08 October, 2023

Article ID: e081023221872 Pages: 25

DOI: 10.2174/0122103155262670230926120458

Price: $65

Open Access Journals Promotions 2
Abstract

Osthole is a coumarin derived natural compound which is an essential ingredient of Traditional Chinese Medicine (TMC) and is widely distributed in nature in plants like Cnidium monnieri (L) Cusson and Angelica pubescens. Current study presents a critical review on description of pharmacological importance of osthole, which is reported to exhibit anticancer, antioxidant, osteogenic, hepatoprotective, neuroprotective, cardiovascular protective, antimicrobial, immuno-modulatory and anti-inflammatory activities. Till date, the reports include pharmacological properties, brief chemistry of advanced methods to explore osthole content in variety of plants. Present review seeks to highlight the sources, biosynthesis, extraction methods, pharmacological properties of the molecule and its derivatives. A brief discussion on patents recently published and granted on the molecule has also been highlighted. Thus the overview of the literature presents the analysis about future possible modalities of the research on this molecule.

Keywords: Osthole, pharmacological profile, biosynthesis, extraction, traditional Chinese medicine, immunomodulatory.

Graphical Abstract

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