Title:Current Medicinal Herbal Advances in the Management of Diabetic
Neuropathy
Volume: 10
Author(s): Neeru singh*, Kulsoom Hamid, Neha Chauhan, Rupesh Kumar Pandey and Lubhan Singh
Affiliation:
- Department of Pharmacology, Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Meerut U.P, 250005, India
Keywords:
Neuropathic pain, diabetes, selaginella, oxidative stress, polyol pathway, plant extracts
Abstract: One of the most common long-term complications of diabetes is a condition known as
diabetic neuropathy. Chronic neuropathic pain is an important and debilitating disease that poses
a huge healthcare challenge. Pathogenesis includes abnormalities in the blood arteries supplying
the peripheral neurons, metabolic diseases such as myo-inositol depletion, and enhanced nonenzymatic glycation, among other things. Several metabolic processes are triggered when neurons
are under oxidative stress, and free radicals are generated. Conventional treatments for neuropathic pain are ineffective despite the abundance of medications on the market today. The use of
herbal-based natural medicines to treat hyperglycemia and its accompanying consequences is
being studied extensively in addition to the commercially available formulations already on the
market. Now that herbal formulations are becoming more common, researchers are paying more
attention to them in medication discovery. Therefore, we conducted a comprehensive assessment
of herbal medicines and plants that have been shown to have a protective effect on neuropathic
pain. Here, the therapeutic effects of each plant have been documented in several neuropathic
pain models in animals and humans. Furthermore, the various mechanisms for the protective
effects are examined. This review's goal is to summarise the current research on herbal-based
therapy for diabetic neuropathy, including pure chemicals derived from plant materials, plant
extracts, and Ayurvedic formulations.
