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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Small Molecule Inhibitors against the Bacterial Pathogen Brucella

Author(s): Yingnan Wu, Ye Guo, Yuheng Ma, Hui Yu* and Zhanli Wang*

Volume 31, Issue 27, 2024

Published on: 28 September, 2023

Page: [4267 - 4285] Pages: 19

DOI: 10.2174/0929867331666230915153910

Price: $65

Abstract

Brucellosis remains one of the major zoonotic diseases worldwide. As a causative agent of brucellosis, it has many ways to evade recognition by the immune system, allowing it to replicate and multiply in the host, causing significant harm to both humans and animals. The pathogenic mechanism of Brucella has not been elucidated, making the identification of drug targets from the pathogenic mechanism a challenge. Metalloenzymatic targets and some protein targets unique to Brucella are exploitable in the development of inhibitors against this disease. The development of specific small molecule inhibitors is urgently needed for brucellosis treatment due to the antibiotic resistance of Brucella. This review summarizes the research on small molecule inhibitors of Brucella, which could be instructive for subsequent studies.

Keywords: Brucellosis, Brucella, drug target, inhibitors, treatment, high-throughput screening.

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