Title:MicroRNAs Regulate Inhibitor of Apoptosis Proteins (IAPs) in Colorectal Cancer
Volume: 12
Issue: 3
Author(s): Hamid Tanzadehpanah, Amir Avan, Majid Ghayour-Mobarhan, Gordon A. Ferns, Hamed Manoochehri, Mohsen Sheykhhasan and Hanie Mahaki*
Affiliation:
- Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Survivin, XIAP, Bruce, Livin, NAIP, miRNA.
Abstract: Colorectal cancer (CRC) is the second most common cause of cancer mortality, with
approximately 1.9 million new cases and 0.9 million deaths globally in 2020. One of the potential
ways to treat colorectal cancer may be through the use of molecular methods to induce cell
apoptosis. Apoptosis is a natural cellular event that regulates the growth and proliferation of
body cells and prevents cancer. In this pathway, several molecules are involved; one group
promotes this process, and some molecules that are representative of inhibitors of apoptosis
proteins (IAPs) inhibit apoptosis. The most important human IAPs include c-IAP1, c-IAP2,
NAIP, Survivin, XIAP, Bruce, ILP-2, and Livin. Several studies have shown that the inhibition
of IAPs may be useful in cancer treatment. MicroRNAs (miRNAs) may be effective in regulating
the expression of various proteins, including those of the IAPs family; they are a large subgroup
of non-coding RNAs that are evolutionarily conserved. Therefore, in this review, the
miRNAs that may be used to target IAPs in colorectal cancer were discussed.
