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Protein & Peptide Letters

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Review Article

Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours

Author(s): Rui Wang, Xia Li, Yangyang Li, Mengjie Zhao, Lida Mi, Weiwei Chen* and Jianxiang Song*

Volume 30, Issue 10, 2023

Published on: 15 September, 2023

Page: [821 - 829] Pages: 9

DOI: 10.2174/0929866530666230915103418

Price: $65

Abstract

Estrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignant tumours, both inhibiting the growth of malignant tumours and promoting their development. In addition, the expression level of SULT1E1 may be regulated by a variety of factors, which in turn affect the growth and therapeutic effects of malignant tumours. The aim of this paper is to review the mechanism of action of SULT1E1 in malignant tumours and the mechanisms that are regulated, in order to provide potential targets for the treatment of malignant tumour patients in the future and theoretical support for the realisation of more personalised and effective therapeutic regimens.

Keywords: Estrogen sulfotransferase, malignant tumors, regulatory factor, SULT1E1, metabolic pathways, therapeutic regimens.

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