Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells
Expressing Specific Biomarkers

Swaroop   Kumar   Pandey; Mradula      Parul; Manikandan      Santhanam
doi:10.2174/1573394719666230911113126
Abstract

Cancer biomarkers or tumor-associated antigens (TAA) are the focus area of current research in cancer biology for diagnosis, prognosis, screening, and targeted treatments. Breast cancer is the second most common type of cancer, affecting women more than men. Conventional methods and antibody-targeted therapies are less effective and suffer systemic cytotoxicity, poor tissue sensitivity, low penetration capacity, and reduced accumulation of the drug in tumor cells that limit its application and sometimes result in treatment failure. Opting for aptamer-mediated targeted delivery of various anti-cancer agents (drugs, siRNA, miRNA, shRNA and peptides) could possibly overcome these limitations by utilizing aptamer as a targeting ligand. The purpose of this article is to review the novel indicative biomarkers of breast cancer and also describe current applications of aptamer-guided active targeting systems in breast cancer therapy in vivo and in vitro.
Keywords: Breast cancer, therapeutics, nanocarriers, drugs, aptamers, biomarkers.
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DOI https://dx.doi.org/10.2174/1573394719666230911113126	Print ISSN 1573-3947
Publisher Name Bentham Science Publisher	Online ISSN 1875-6301
Current Cancer Therapy Reviews

Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers

Abstract

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Advancements in Lipid Nanoparticle Delivery Systems for mRNA Therapeutics

Current Progress in Protein Degradation and Cancer Therapy

Current Cancer Therapy Reviews

Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers

Abstract

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Advancements in Lipid Nanoparticle Delivery Systems for mRNA Therapeutics

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