Title:Pharmacological Potential of Bioactive Peptides for the Treatment
of Diseases Associated with Alzheimer's and Brain Disorders
Volume: 24
Issue: 8
Author(s): Jeetendra Kumar Gupta and Kuldeep Singh*
Affiliation:
- Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar
Pradesh, India
Keywords:
Bioactive peptides, naturally occurring proteins, beneficial properties, alzheimer's and brain disorders, traditional pharmacological treatments.
Abstract: Bioactive peptides are a promising class of therapeutics for the treatment of
diseases associated with Alzheimer's and brain disorders. These peptides are derived
from naturally occurring proteins and have been shown to possess a variety of beneficial
properties. They may modulate neurotransmitter systems, reduce inflammation, and
improve cognitive performance. In addition, bioactive peptides have the potential to
target specific molecular pathways involved in the pathogenesis of Alzheimer's and brain
disorders. For example, peptides have been shown to interact with amyloid-beta, a
major component of amyloid plaques found in Alzheimer's disease, and have been
shown to reduce its accumulation in the brain. Furthermore, peptides have been found to
modulate the activity of glutamate receptors, which are important for memory and
learning, as well as to inhibit the activity of enzymes involved in the formation of toxic
amyloid-beta aggregates. Finally, bioactive peptides have the potential to reduce
oxidative stress and inflammation, two major components of many neurological
disorders. These peptides could be used alone or in combination with traditional
pharmacological treatments to improve the management of diseases associated with
Alzheimer's and brain disorders.
