Title:Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?
Volume: 24
Issue: 12
关键词:
氧化应激，精神疾病，中枢神经系统，抑郁症，焦虑症，中枢神经系统功能异常。
摘要: The biochemical integrity of the brain is critical in maintaining normal central
nervous system (CNS) functions. One of the factors that plays an important role in
causing biochemical impairment of the brain is known as oxidative stress. Oxidative
stress is generally defined as the excessive formation of free radicals relative to
antioxidant defenses. The brain is particularly susceptible to oxidative stress because of
its high oxygen consumption and lipid-rich content. Therefore, oxidative stress damage
is associated with abnormal CNS function. Psychiatric disorders are debilitating
diseases. The underlying pathophysiology of psychiatric disorders is poorly defined and
may involve the interplay of numerous clinical factors and mechanistic mechanisms.
Considerable evidence suggests that oxidative stress plays a complex role in several
neuropsychiatric disorders, including anxiety, bipolar disorder, depression, obsessivecompulsive
disorder, panic disorder, and schizophrenia. To address these issues, we
reviewed the literature and considered the role of oxidative stress as one of the first
pathological changes in the course of neuropsychiatric disorders, which should receive
more attention in future research.
