Title:Validity of the Mean Platelet Volume and Revised Clinical Risk Index for Babies
(CRIB-II) Score to Assess Mortality Risk in Preterm Infants
Volume: 5
Author(s): Atef Alshafei*, Entesar Zawam, Mahmoud Galal, Anwar Khan, Yaser El Saba and Moustafa Hassan
Affiliation:
- NICU, Pediatric Department, Dubai Hospital, Dubai, United Arab Emirates
Keywords:
CRIB II, Mean platelet volume, Preterm infant, Mortality, Neonatal intensive care, Automated hematology analyzer. Article
Abstract:
Objective:
This study aimed to investigate the validity of the mean platelet volume (MPV) alone and MPV combined with the revised Clinical Risk Index for
Babies (CRIB II) score to predict neonatal mortality in preterm infants.
Materials and Methods:
This retrospective observational study performed between May 2018 and June 2021 included preterm neonates (gestational age 23–32 weeks)
admitted to a tertiary neonatal intensive care unit (NICU) within 12 hours of birth, who were followed up until death or discharge. MPV was
recorded at admission and within 72 hours before death or discharge. The CRIB II score variables were assessed within 12 hours of birth, and the
area under the receiver operating characteristic curve (AUC) was calculated for the MPV and CRIB II scores to predict neonatal mortality.
Results:
We investigated 404 newborns, of whom 28 (6.9%) died. The mean neonatal gestational age was 28.6±2.8 weeks. The MPV was significantly
higher in non-survivors than in survivors (p=0.001). The AUC for the MPV and the CRIB II score was 0.68 (95% CI: 0.55–0.80) and 0.85 (95%
CI: 0.79–0.91), respectively. The AUC for the MPV combined with the CRIB II score was 0.91 (95% CI 0.87–0.95). The difference in MPV at
birth between survivors and non-survivors was statistically non-significant.
Conclusion:
MPV was found to be a poorer predictor of neonatal mortality than the CRIB II score; however, MPV combined with the CRIB II score
demonstrated significantly improved predictive ability for preterm infant mortality risk.
