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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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General Review Article

Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis

Author(s): Zohreh Salimi, Mehdi Rostami, Yaser Eshaghi Milasi, Alireza Mafi, Ramin Raoufinia, Amirhossein Kiani, Fariba Sakhaei, Behrooz Ghezelbash, Alexandra E. Butler, Maryam Mohammad-Sadeghipour* and Amirhossein Sahebkar*

Volume 25, Issue 1, 2024

Published on: 06 September, 2023

Page: [59 - 70] Pages: 12

DOI: 10.2174/1389203724666230822085951

Price: $65

Abstract

Frequent exposure to various external and internal adverse forces (stresses) disrupts cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, fibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to activating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of the consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and specifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.

Keywords: Stresses, endoplasmic reticulum, hepatic satellite cells, unfolded protein response, liver fibrosis, drug therapy.

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