Title:Polymeric Gel Scaffolds and Biomimetic Environments for Wound Healing
Volume: 29
Issue: 40
Author(s): Alka, Abhishek Verma, Nidhi Mishra, Neelu Singh, Priya Singh, Raquibun Nisha, Ravi Raj Pal and Shubhini A. Saraf*
Affiliation:
- Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University Lucknow (A Central University), Uttar Pradesh, Vidya Vihar, Raebareli Road, Lucknow, 226025, Uttar Pradesh, India
- National Institute of Pharmaceutical Education and
Research (NIPER), Raebareli, Bijnor-Sisendi Road, Sarojini Nagar, Lucknow, 226002, Uttar Pradesh, India
Keywords:
Wound healing, hydrogel, scaffolds, polymers, tissue regeneration, extracellular matrix.
Abstract: Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying
and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed.
Effective wound care becomes a bigger problem when various traditional wound healing methods and
products may not only fail to promote good healing. Still, it may also hinder the healing process, causing
wounds to stay open longer. Progress in tissue regeneration has led to developing three-dimensional scaffolds
(3D) or constructs that can be leveraged to facilitate cell growth and regeneration while preventing infection
and accelerating wound healing. Tissue regeneration uses natural and fabricated biomaterials that encourage the
growth of tissues or organs. Even though the clinical need is urgent, the demand for polymer-based therapeutic
techniques for skin tissue abnormalities has grown quickly. Hydrogel scaffolds have become one of the most
imperative 3D cross-linked scaffolds for tissue regeneration because they can hold water perfectly and are porous,
biocompatible, biodegradable, and biomimetic. For damaged organs or tissues to heal well, the porosity
topography of the natural extracellular matrix (ECM) should be imitated. This review details the scaffolds that
heal wounds and helps skin tissue to develop. After a brief overview of the bioactive and drug-loaded polymeric
hydrogels, the discussion moves on to how the scaffolds are made and what they are made of. It highlights
the present uses of in vitro and in-vivo employed biomimetic scaffolds. The prospects of how well bioactiveloaded
hydrogels heal wounds and how nanotechnology assists in healing and regeneration have been discussed.
