Title:Relationship Between Vitamin D Level and Index of Cardio
Electrophysiological Balance in Children
Volume: 27
Issue: 14
Author(s): Ahmet Guzelcicek*, Emrullah Kilinc, Halil Fedai, Necip Fazıl Dedeoglu, Kenan Toprak, Mustafa Begenc Tascanov, Metin Ocak, Bülent Gungorer and Dogan Kose
Affiliation:
- Department of Pediatrics, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Keywords:
Vitamin D deficiency, iCEB, ventricular arrhythmia, SCD, ECG, QTC.
Abstract:
Background: Vitamin D deficiency has been found to be associated with various cardiovascular
disorders, including hypertension, coronary artery disease, heart failure, peripheral vascular
diseases, and sudden cardiac death. In the literature, it has been reported that many electrocardiographic
parameters have been developed to predict ventricular arrhythmias. In recent studies,
it is noteworthy that the index of cardio-electrophysiological balance (iCEB) and correct cardioelectrophysiological
balance (iCEBc), which are electrocardiographic parameters, can be used as
new, easy, cheap and non-invasive parameters to predict ventricular arrhythmias.
Objective: This study aimed to investigate the relationship between vitamin D deficiency and iCEB
and iCEBc values in children.
Methods: A total of 186 patients were included in this study. Group 1 included 114 patients with vitamin
D levels below 20 ng/ml; 50 patients with vitamin D levels of 21-29 ng/ml were included in Group 2;
Group 3 consisted of 36 patients with a vitamin D level above 30 ng/ml. iCEB and iCEBc values were
calculated by taking 12-lead ECG from all individuals and comparing them between groups.
Results: A total of 186 children, 114 subjects in Group 1, 36 subjects in Group 2, and 36 subjects in
Group 3, were included in the study. Demographic characteristics and height-weight values of the groups
were similar. Significant differences were found between the groups in terms of QT, QTc, QT/QRS, and
QTc/QRS levels (p: 0.003, 0.028, 0.001, and 0.001, respectively). In the correlation analysis, a negative
correlation was found between QTc/QRS and vitamin D level (r=-0.320, p=<0.001) and between
QT/QRS and vitamin D level (r=-0.268, p=<0.001). Moreover, vitamin D level (β=0.389, p<0.001) was
determined as an independent predictor of QTc/QRS in multivariate logistic regression analysis.
Conclusion: iCEB and iCEBc parameters increase significantly in children with low vitamin D
levels. These parameters are also evaluated during the follow-up of children with vitamin D deficiency
in terms of the risk of ventricular arrhythmia. iCEBc can be used as an easy, inexpensive,
non-invasive, and reproducible parameter.
