Title:Uterine Cancer: A Nine-year Review from a Tertiary Hospital in Tamil
Nadu
Volume: 20
Issue: 5
Author(s): Krishnapriya Leela, Chippy Tess Mathew*Umamaheswari Gurusamy
Affiliation:
- Department of Obstetrics and Gynecology, PSG Institute of Medical Sciences & Research, Coimbatore, India
Keywords:
Uterine cancer, demographic factors, grading, staging, obese, parity.
Abstract:
Background: With increasing uterine cancer in developing nations, there is a need for timely
determination of the diagnosis, prognosis, and management options to reduce morbidity and mortality.
Objective: To analyze the socio-demographic, etio-pathological features and management of uterine
cancer and evaluate its correlation with grading/staging in our population.
Methods: This retrospective descriptive study analyzed data from 97 histologically proven uterine
cancer cases. Age, parity, symptoms, co-morbidities, body mass index (BMI), ultrasound features, histopathology
type, stage and grade of the tumor, type of hysterectomy done, complications and mortality
were analysed. Statistical analysis was done using ANOVA and chi-square test, and a p-value<0.05
indicated statistical significance.
Results: The mean age of diagnosis was 57.91 years, and the mean BMI was 29.32 Kg/m2. Majority
of the patients were multiparous (42.27%), and only 10% were nulliparous. The disease was detected
at an earlier age in nulliparous and obese women. Diabetes and hypertension were found in 75.25%.
Most of the patients were detected with stage I cancer (80.6%). Patients diagnosed with uterine cancer
on biopsy were treated with total abdominal hysterectomy with bilateral salpingo-oophorectomy andbilateral
pelvic lymph node dissection (55.8%). Over 36% of patients received postop radiotherapy
and/or chemotherapy. 21% patients were lost to follow-up and 12.37% died. Also, 24 cases had postoperative
complications (wound infection).
Conclusion: Uterine cancer is common among obese women with diabetes and hypertension. In
nulliparous and the obese, the cancer was detected at an earlier age. Most of our patients had stage 1
disease, and 90% was endometroid cancer. The study highlights the importance of endometrial
sampling before hysterectomy in perimenopausal women to avoid suboptimal surgery in patients
diagnosed with uterine cancer after a simple hysterectomy.
