Title:Prognostic Value of Red Blood Cell Distribution Width and Hemoglobin in
Patients with Spontaneous Intracerebral Hemorrhage
Volume: 20
Issue: 3
Author(s): Jiaping Xu, Xin Sun, Weiyin Cao, Huan Wu, Xinjia Pan, Linchi Wang, Yi Zhou, Wanqing Zhai, Shoujiang You*Yongjun Cao*
Affiliation:
- Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of
Soochow University, Suzhou, 215004, China
- Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of
Soochow University, Suzhou, 215004, China
- Institutes of Neuroscience, Soochow University, Suzhou, 215123, China
Keywords:
Red blood cell distribution width, hemoglobin, intracerebral hemorrhage, mortality, hematoma expansion, complete blood count.
Abstract:
Background: The association between baseline red blood cell distribution width (RDW)
and hemoglobin levels and outcomes after acute intracerebral hemorrhage (ICH) is not well studied.
We aimed to investigate the association between baseline RDW and hemoglobin levels with
early hematoma expansion (HE) and mortality at 3 months and 1 year in acute ICH patients.
Methods: A total of 393 ICH patients from January 2014 to February 2019 were included. Patients
were divided into four groups based on quartiles of RDW and hemoglobin levels at admission, respectively.
Logistic regression models were used to estimate the effect of the levels of RDW and
hemoglobin on early HE (absolute hematoma growth >6 mL from baseline to follow-up) and allcaused
mortality at 3 months and 1 year.
Results: There were no significant associations between baseline RDW and hemoglobin levels and
early HE. The 3-month mortality (adjusted odds ratio [OR] 2.88; 95% confidence intervals [CI]
0.96-8.64) and 1-year mortality (adjusted OR 3.16, 95% CI 1.08-9.21) was significantly higher in
patients with the highest RDW level (Q4) compared to those with the lowest RDW level (Q1).
Moreover, patients with the lowest hemoglobin level were significantly associated with increased
odds of all-cause mortality at 3-month (adjusted OR 3.95, 95% CI 1.26-12.4) and 1-year (adjusted
OR 4.42, 95% CI 1.56-12.5) compared to those with highest hemoglobin level.
Conclusion: In patients with acute ICH, a higher level of RDW at admission significantly increased
the risk of all-cause mortality at 1 year. Moreover, a decreased hemoglobin level at admission
was also associated with a higher risk of all-cause mortality at 3 months and 1 year.
